{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T14:28:47Z","timestamp":1778336927668,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T00:00:00Z","timestamp":1396483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to detect the possible role of methylene tetrahydrofolate reductase gene polymorphism (<jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content> C677T) in the pathogenesis of lymphoid neoplasms and to investigate the influence of this polymorphism on methotrexate toxicity in adult ALL patients treated with methotrexate maintenance therapy. There was a statistically significant increase in the risk of non\u2010<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>odgkin lymphoma in patients with <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> genotype (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 2.9; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.3\u20136.3; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.007) and combined <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> genotype (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 3.2; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.5\u20136.6; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006). While no significant association was found between this polymorphism and <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> risk. The patients with <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> treated with methotrexate during maintenance therapy were observed for signs of toxicity. <jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content> 677C&gt;T polymorphism (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>) was significantly overrepresented among cases with hepatic toxicity (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a015.6; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 2.6\u201381.3; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). In addition, they were overrepresented among cases with mucositis, anemia, thrombocytopenia, and leukopenia. However, it did not reach statistical significance level. Further studies on larger number of subjects are necessary. Additional studies on the role of <jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content> gene polymorphism with environment (folate intake) interaction are needed to confirm the role of these genetic polymorphisms.<\/jats:p>","DOI":"10.1111\/ejh.12302","type":"journal-article","created":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T17:52:47Z","timestamp":1393955567000},"page":"63-69","source":"Crossref","is-referenced-by-count":19,"title":["<scp>MTHFR<\/scp> C677T polymorphism: association with lymphoid neoplasm and effect on methotrexate therapy"],"prefix":"10.1111","volume":"93","author":[{"given":"Mona W.","family":"Ayad","sequence":"first","affiliation":[{"name":"Clinical Pathology Department Faculty of Medicine University of Alexandria Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amel A.","family":"El Naggar","sequence":"additional","affiliation":[{"name":"Haematology Department Medical Research Institute University of 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