{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T15:32:33Z","timestamp":1726759953131},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T00:00:00Z","timestamp":1398211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>There is strong evidence that certain thrombophilic single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) account for an increased risk of thrombosis. The additive impact of inherited thrombotic risk factors to a certain disease\u2010 immanent thrombotic risk is vastly unknown. Therefore, we aimed to investigate the influence of three novel, preselected<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s on the risk of thrombosis in patients diagnosed with myeloproliferative neoplasm (<jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In 167 patients with a diagnosis of essential thrombocythemia (<jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>) or prefibrotic primary myelofibrosis (<jats:styled-content style=\"fixed-case\">PMF<\/jats:styled-content>) thrombophilic<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s in the genes of factor<jats:styled-content style=\"fixed-case\">VII<\/jats:styled-content>(F7), nitric oxide synthase 3 (<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>3) and Fc\u0263<jats:styled-content style=\"fixed-case\">RII<\/jats:styled-content>a (<jats:styled-content style=\"fixed-case\">FCGR<\/jats:styled-content>2A) were determined. Subsequently, the polymorphic variants were correlated with the incidence of major thrombosis after diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Decanucleotide insertion polymorphism of F7 emerged as an independent, significant risk factor for total thrombosis and arterial thrombosis in particular in the whole group of patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0007) as well as in the separate analysis of patients with<jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>(<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results illustrate that the risk of thrombosis in<jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content>is significantly multiplied by inherited thrombophilic<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s. This result points to the importance of a combined consideration of the inherited and the acquired hypercoagulable state in patients with<jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content>. Larger studies are needed to confirm and extend these important findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12307","type":"journal-article","created":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T18:14:12Z","timestamp":1394561652000},"page":"103-111","source":"Crossref","is-referenced-by-count":12,"title":["Decanucleotide insertion polymorphism of F7 significantly influences the risk of thrombosis in patients with essential thrombocythemia"],"prefix":"10.1111","volume":"93","author":[{"given":"Veronika","family":"Buxhofer\u2010Ausch","sequence":"first","affiliation":[{"name":"Division of Hematology and Blood Coagulation Department of Internal Medicine I Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damla","family":"Olcaydu","sequence":"additional","affiliation":[{"name":"Center for Molecular Medicine of the Austrian Academy of Sciences Vienna 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