{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:25:43Z","timestamp":1790663143106,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T00:00:00Z","timestamp":1396828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>T\u2010cell large granular lymphocytic leukemia (T\u2010LGLL) is a rare indolent lymphoproliferative disorder characterized by cytopenias, splenomegaly, and various degrees of T\u2010cell lymphocytosis, due to a clonal expansion of CD8\u2010positive cytotoxic T\u2010cells. Phenotypic variants of T\u2010LGLL include CD4<jats:sup>+<\/jats:sup>\/CD8<jats:sup>\u2212<\/jats:sup> T\u2010cells, with dual CD4<jats:sup>\u2212<\/jats:sup>\/CD8<jats:sup>\u2212<\/jats:sup>\/\u03b3\u03b4<jats:sup>+<\/jats:sup> T\u2010cells being even rarer. Cytogenetic abnormalities in T\u2010LGLL have rarely been reported, and there is scientific debate regarding the existence of aggressive or transformed variants of T\u2010LGLL. We report a patient with T\u2010LGLL, \u03b3\u03b4 variant, with nearly 20\u2010year\u2010long duration of cytopenias before transformation to an unusual clinical scenario, manifesting with marked lymphocytosis &gt;100\u00a0\u00d7 10<jats:sup>9<\/jats:sup>\/L and infiltration of lymph nodes, tonsils, and subcutaneous tissue. Single\u2010nucleotide polymorphism assays revealed acquired copy neutral loss of heterozygosity at 17q and deletion of 3p21.31, in addition to trisomy 5, monosomy X, and monosomy 21. These genetic abnormalities provided a better understanding of the molecular nature and the potentiality of disease transformation.<\/jats:p>","DOI":"10.1111\/ejh.12313","type":"journal-article","created":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T08:53:09Z","timestamp":1395046389000},"page":"260-264","source":"Crossref","is-referenced-by-count":11,"title":["Transformed aggressive \u03b3\u03b4\u2010variant T\u2010cell large granular lymphocytic leukemia with acquired copy neutral loss of heterozygosity at 17q11.2q25.3 and additional aberrations"],"prefix":"10.1111","volume":"93","author":[{"given":"Ling","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hematopathology and Laboratory Medicine H Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhakrishnan","family":"Ramchandren","sequence":"additional","affiliation":[{"name":"Department of Oncology Barbara Ann Karmanos Cancer Center Wayne State University Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Papenhausen","sequence":"additional","affiliation":[{"name":"Department of Cytogenetics Integrated Oncology\u2010Laboratory Corporation of America Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P.","family":"Loughran","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Virginia Cancer Center Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubomir","family":"Sokol","sequence":"additional","affiliation":[{"name":"Department of Hematologic Malignancies H Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1620.bloodjournal8451620"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20853"},{"key":"e_1_2_8_4_1","first-page":"272","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Chan WC","year":"2008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.7.2315.2315"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.11-3-263"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPTFFQ18JMYKDF"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2007.04.011"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404112"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-5028-9_16"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1675"},{"key":"e_1_2_8_12_1","first-page":"292","volume-title":"WHO Classification of Tumors of Hematopoietic and Lymphoid Tissue","author":"Gaulard P","year":"2008"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114885"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-474577"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp552"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-10-201848"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-2754"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.08056.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-095075"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.9.1876"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(02)00796-3"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00443.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805003105"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12313","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T07:33:46Z","timestamp":1696318426000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,7]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1111\/ejh.12313"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12313","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,7]]}}}