{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:09:09Z","timestamp":1785452949125,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T00:00:00Z","timestamp":1397088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Financial support was provided through the regional agreement in medical training and Clinical research (ALF) between Stockholm City Council and Karolinska Institute. Etical nr 549\/03"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to assess the ovarian function, fertility and bone mineral density in women who previously had treatment for different haematological malignancies (<jats:styled-content style=\"fixed-case\">HM<\/jats:styled-content>s). The overall survival and cure rates of patients with <jats:styled-content style=\"fixed-case\">HM<\/jats:styled-content>s have improved dramatically. The treatment affects fertility and bone density. Fifty\u2010two premenopausal women, from Stockholm region, were included in the study between 1998 and 2002, followed until 2011. The diagnoses were acute lymphoblastic leukaemia (<jats:italic>n<\/jats:italic>\u00a0=\u00a06), acute myeloid leukaemia (<jats:italic>n<\/jats:italic>\u00a0=\u00a010), chronic lymphocytic leukaemia (<jats:italic>n<\/jats:italic>\u00a0=\u00a01), chronic myeloid leukaemia (<jats:italic>n<\/jats:italic>\u00a0=\u00a012), Hodgkin lymphoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a012) and non\u2010Hodgkin lymphoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a011). Before treatment, women without children (43\/52), when possible, were offered fertility preservation options. The mean age at diagnosis was 27, at final evaluation 39\u00a0yr. Thirty\u2010seven patients received <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>; 26 allogeneic, 11 autologous. Before allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, nineteen patients had myeloablative conditioning; seven had reduced\u2010intensity conditioning. Eleven patients got total body irradiation. Eight patients were transplanted with grafts from an <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010identical sibling donor, while 18 had unrelated donors. All women were in a menopausal state post\u2010therapy. Hormone replacement therapy (HRT) was given, and bone mineral density (<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>) was measured every other year. The serum levels of parathyroid hormone (PTH), free and bound calcium was within normal range. <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> measurements showed a slight increase over time in the spine with a mean of 0.015\u00a0g\/cm<jats:sup>2<\/jats:sup>\/yr. Four spontaneous pregnancies resulted in two babies and two discontinued pregnancies; two pregnancies were achieved with oocyte donation and surrogacy and one woman adopted a child. <jats:styled-content style=\"fixed-case\">HRT<\/jats:styled-content> sustains <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> in long\u2010term survivors from <jats:styled-content style=\"fixed-case\">HM<\/jats:styled-content>s. This study highlights the importance of <jats:styled-content style=\"fixed-case\">HRT<\/jats:styled-content> and fertility issues in this patient group.<\/jats:p>","DOI":"10.1111\/ejh.12317","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T19:05:15Z","timestamp":1395342315000},"page":"137-142","source":"Crossref","is-referenced-by-count":14,"title":["Long\u2010term follow\u2010up of bone density, general and reproductive health in female survivors after treatment for haematological malignancies"],"prefix":"10.1111","volume":"93","author":[{"given":"Sabine","family":"Naess\u00e9n","sequence":"first","affiliation":[{"name":"Department of Woman and Child Health Division of Obstetrics and Gynecology Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Bergstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Clinical Science Intervention and Technology 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