{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:17:17Z","timestamp":1761513437061},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T00:00:00Z","timestamp":1397001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immune thrombocytopenia (<jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>) is a disorder characterised by immune\u2010mediated accelerated platelet destruction and suppressed platelet production. In the bone marrow examinations of patients with <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>, some investigators found megakaryocyte numbers to be increased while others have found them to be normal. Although recent guidelines recommend against bone marrow examinations in typical <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> patients, the recent introduction of thrombopoietin receptor agonists as an effective treatment for <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> has refocused attention on abnormalities of bone marrow megakaryocytes. In this study, we retrospectively analysed the bone marrow aspiration, flow cytometry\u2010<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>45 side scatter (<jats:styled-content style=\"fixed-case\">SSC<\/jats:styled-content>) and biopsy results of our patients with <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> by dividing them into two groups according to age (&lt;60\u00a0yr and \u226560\u00a0yr). Ninety eight newly diagnosed <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> patients were included in the study. <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>45 <jats:styled-content style=\"fixed-case\">SSC<\/jats:styled-content> results were recorded as percentages of normoblasts, granulocytes, lymphocytes, monocytes and myeloid\/erythroid ratio. Length of the biopsy specimen, cellularity, presence of dysplasia or fibrosis with number, morphology and distribution of megakaryocytes were recorded. In group 1, there were 49 patients. Mean age was 41.31\u00a0\u00b1\u00a012.77\u00a0yr. In group 2, there were 49 patients. Mean age was 70.78\u00a0\u00b1\u00a07.88\u00a0yr. Megakaryocyte numbers on bone marrow aspirates were not recorded in most patients, so we could not comment on this point. Flow cytometry results and bone marrow findings were similar between two groups. In conclusion, there is no difference between bone marrow examinations of young and older patients with <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>, and biopsy should not be recommended in typical <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> patients as already mentioned in guidelines.<\/jats:p>","DOI":"10.1111\/ejh.12320","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T04:32:09Z","timestamp":1395721929000},"page":"157-160","source":"Crossref","is-referenced-by-count":3,"title":["Bone marrow examination in patients with immune thrombocytopenia: is there anything different in older patients?"],"prefix":"10.1111","volume":"93","author":[{"given":"Eren","family":"Gunduz","sequence":"first","affiliation":[{"name":"Department of Hematology School of Medicine Eskisehir Osmangazi University Eskisehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Banu Kara","family":"Kivanc","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine School of Medicine Eskisehir Osmangazi University Eskisehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz","family":"Arik","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Eskisehir Osmangazi University Eskisehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serap","family":"\u0130siksoy","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Eskisehir Osmangazi University Eskisehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cengiz","family":"Bal","sequence":"additional","affiliation":[{"name":"Department of Biostatistics School of Medicine Eskisehir Osmangazi University Eskisehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga 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