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A state of chronic inflammation is shared by them all, YKL\u201040 also being involved in the severity of chronic endothelial inflammation, which today is considered of crucial importance for the development of atherosclerosis. The MPNs being cancers with a heavy burden of cardiovascular diseases we hypothesised that circulating YKL\u201040 might reflect the inflammatory process and potentially serve as a novel disease marker. Using ELISA, we measured YKL\u201040 in 15 patients with ET, 16 patients with PV, 17 patients with PMF and 30 healthy controls. YKL\u201040 was significantly elevated in PMF vs. control subjects, PMF levels median 43\u00a0ng\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> vs. controls median 28\u00a0ng\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>,<jats:italic> P<\/jats:italic>\u00a0=\u00a00.033. An increase from ET over PV may reflect the integrated impact of disease processes in MPNs.<\/jats:p>","DOI":"10.1111\/ejh.12332","type":"journal-article","created":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T05:13:19Z","timestamp":1396415599000},"page":"224-228","source":"Crossref","is-referenced-by-count":25,"title":["Circulating <scp>YKL<\/scp>\u201040 in myelofibrosis a potential novel biomarker of disease activity and the inflammatory state"],"prefix":"10.1111","volume":"93","author":[{"given":"Mads Emil","family":"Bj\u00f8rn","sequence":"first","affiliation":[{"name":"Institute for Inflammation Research Department of Infectious Diseases and Rheumatology Copenhagen University Hospital Rigshospitalet Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christen Lykkegaard","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Hematology Roskilde Hospital Copenhagen University Hospital Roskild 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