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The <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uropean <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>rganisation for <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>esearch and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reatment of <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ancer <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>uality of <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ife <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>uestionnaire <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ore 30 (<jats:styled-content style=\"fixed-case\">EORTC QLQ<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>30) was completed twice, with a 1\u2010yr interval. This questionnaire was also completed by an age\u2010 and sex\u2010matched normative population (<jats:italic>N<\/jats:italic>\u00a0=\u00a0580). Detailed data on treatment were extracted from the cancer registry and Population\u2010based <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>ematological <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>egistry for <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>bservational <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tudies (<jats:styled-content style=\"fixed-case\">PHAROS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 181 patients who were invited, 148 responded (82%, <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1). Patients treated with immunochemotherapy reported clinically relevant higher mean fatigue scores than those who underwent radiotherapy (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). No differences were observed on the other <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> scales between treatment groups. Mean <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> scores were worse for <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> patients treated with immunochemotherapy compared with a normative population (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). A quarter to 50% of patients persistently reported to be slowed down, lethargic, or persistently worried about future health or was limited in social activities. Subsequently, patients reporting these symptoms\/worries had a lower global health status\/<jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Alertness for persistent symptoms that occur during and after treatment of <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> patients is needed and may help to avoid lasting negative influence on their <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12335","type":"journal-article","created":{"date-parts":[[2014,4,5]],"date-time":"2014-04-05T06:57:24Z","timestamp":1396681044000},"page":"229-238","source":"Crossref","is-referenced-by-count":27,"title":["Impact of therapy and disease\u2010related symptoms on health\u2010related quality of life in patients with follicular lymphoma: results of the population\u2010based <scp>PHAROS<\/scp>\u2010registry"],"prefix":"10.1111","volume":"93","author":[{"given":"Simone","family":"Oerlemans","sequence":"first","affiliation":[{"name":"Comprehensive Cancer Centre Netherlands Eindhoven Cancer Registry Eindhoven The Netherlands"},{"name":"Center of Research on Psychology in Somatic Diseases (CoRPS) Tilburg University Tilburg The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djamila E.","family":"Issa","sequence":"additional","affiliation":[{"name":"Department of Hematology VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther C.","family":"van den Broek","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Centre Netherlands Eindhoven Cancer Registry Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marten R.","family":"Nijziel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Hemato\u2010Oncology M\u00e1xima Medical Center Eindhoven\u2010Veldhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Willem W.","family":"Coebergh","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Centre Netherlands Eindhoven Cancer Registry Eindhoven The Netherlands"},{"name":"Department of Public Health Erasmus University Medical Centre Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floortje","family":"Mols","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Centre Netherlands Eindhoven Cancer Registry Eindhoven The Netherlands"},{"name":"Center of Research on Psychology in Somatic Diseases (CoRPS) Tilburg University Tilburg The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lonneke V.","family":"van de Poll\u2010Franse","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Centre Netherlands Eindhoven Cancer Registry Eindhoven The Netherlands"},{"name":"Center of Research on Psychology in Somatic Diseases (CoRPS) Tilburg University Tilburg The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,26]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Cancer in the Netherlands until 2020, Trends and Prognoses [Kanker in Nederland tot 2020, Trends en prognoses]","author":"Dutch Cancer Society","year":"2011"},{"key":"e_1_2_8_3_1","volume-title":"SEER Cancer Statistics Review, 1975\u20132009","author":"Howlader N"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds517"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2013.1.561"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.5026"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.593270"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2005.00438.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1385\/MO:18:1:85"},{"key":"e_1_2_8_11_1","first-page":"973","article-title":"Quality of life assessment in elderly patients with aggressive non\u2010Hodgkin's Lymphoma treated with anthracycline\u2010containing regimens. 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