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This pain of variable severity, also referred as persistent pain in the <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> literature, contributes to significant morbidity and poor quality of life and often fails to respond adequately to standard <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> therapies. In this article, we briefly describe types of pain encountered in <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> with a special emphasis on persistent pain. We discuss altered pain processing as a potential contributing mechanism, which may lead to development and maintenance of persistent pain. We describe the advances in the non\u2010<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> pain field that may help improve the understanding of <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> pain. We highlight the need for further investigation in this area because some of these patients with persistent pain may benefit from receiving adjuvant mechanism\u2010based therapies used successfully in other non\u2010<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> chronic pain conditions.<\/jats:p>","DOI":"10.1111\/ejh.12340","type":"journal-article","created":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T17:54:41Z","timestamp":1397584481000},"page":"89-95","source":"Crossref","is-referenced-by-count":60,"title":["Thinking beyond sickling to better understand pain in sickle cell disease"],"prefix":"10.1111","volume":"93","author":[{"given":"Deepika S.","family":"Darbari","sequence":"first","affiliation":[{"name":"Division of Hematology Department of Pediatrics Center for Cancer and Blood Disorders Children's National Medical Center George Washington University Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir 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