{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T13:02:25Z","timestamp":1761310945470},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T00:00:00Z","timestamp":1399852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"European Regional Development Found","award":["ITMS 26240120023"],"award-info":[{"award-number":["ITMS 26240120023"]}]},{"name":"Grant of Comenius University for young researchers","award":["UK\/590\/2013"],"award-info":[{"award-number":["UK\/590\/2013"]}]},{"name":"Grant of Comenius University for young researchers","award":["UK\/279\/2012"],"award-info":[{"award-number":["UK\/279\/2012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>Warfarin represents the most commonly prescribed oral anticoagulants, which functions as an antagonist of vitamin K<\/jats:styled-content>, an essential factor of blood coagulation cascade. Warfarin has a narrow therapeutic index. An insufficient dose can cause failure of antithrombotic effect, and an overdose increases a risk of bleeding. It is known that variability in two genes (CYP2C9<\/jats:italic><\/jats:styled-content> and VKORC1<\/jats:italic><\/jats:styled-content>) has a significant effect on individual response to warfarin dose. These polymorphisms influence more than one\u2010third of known warfarin dose effect. Pharmacogenetics of warfarin is less affected by polymorphisms in the other genes such as CYP4F2<\/jats:italic><\/jats:styled-content>, <\/jats:italic>CYP2C19<\/jats:italic><\/jats:styled-content>, and GGCX<\/jats:italic><\/jats:styled-content>.<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>The frequency of selected single nucleotide polymorphisms including CYP<\/jats:styled-content>2C<\/jats:styled-content>9*2 (430C<\/jats:styled-content>>T), CYP<\/jats:styled-content>2C<\/jats:styled-content>9*3 (1075A<\/jats:styled-content>>C<\/jats:styled-content>), VKORC<\/jats:styled-content>1*2 (\u22121639G<\/jats:styled-content>>A<\/jats:styled-content>\/1173C<\/jats:styled-content>>T<\/jats:styled-content>), VKORC<\/jats:styled-content>1*3 (3730G<\/jats:styled-content>>A<\/jats:styled-content>), GGCX<\/jats:styled-content> (12970C<\/jats:styled-content>>G<\/jats:styled-content>, 8016G<\/jats:styled-content>>A<\/jats:styled-content>), CYP<\/jats:styled-content>2C<\/jats:styled-content>19*2 (681G<\/jats:styled-content>>A<\/jats:styled-content>), and CYP<\/jats:styled-content>4F<\/jats:styled-content>2*3 (1297G<\/jats:styled-content>>A<\/jats:styled-content>) was tested in a control group consisting of 112 randomly selected individuals by allele\u2010specific real\u2010time PCR<\/jats:styled-content>, restriction fragment length polymorphism, and bidirectional PCR<\/jats:styled-content> allele\u2010specific amplification.<\/jats:p><\/jats:sec>Results and Discussion<\/jats:title>The current results were statistically evaluated and compared with other populations. The presented results in S<\/jats:styled-content>lovak population which is in H<\/jats:styled-content>ardy\u2013W<\/jats:styled-content>einberg equilibrium were compared with the prevalence in different countries. The incidence of selected polymorphisms in S<\/jats:styled-content>lovak population correlates with C<\/jats:styled-content>aucasians.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12348","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T15:55:51Z","timestamp":1398095751000},"page":"320-328","source":"Crossref","is-referenced-by-count":7,"title":["Frequency of selected single nucleotide polymorphisms influencing the warfarin pharmacogenetics in S<\/scp>lovak population"],"prefix":"10.1111","volume":"93","author":[{"given":"\u013dubica","family":"Kraj\u010d\u00edov\u00e1","sequence":"first","affiliation":[{"name":"1st Department of Neurology University Hospital Bratislava Slovakia"},{"name":"Institute of Medical Biology, Genetics and Clinical Genetics Comenius University Faculty of Medicine and University Hospital Bratislava 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