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Here, we describe a case of unexpected and rapid onset of symptomatic peripheral artery disease (<jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content>) associated with silent stenosis of digestive and renal arteries in a nilotinib\u2010treated patient devoid of significant cardiovascular diseases (<jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>) risk factor, prior atherosclerotic disease, or other cause of arterial damage. This is the first report to establish a direct relationship between nilotinib exposure and <jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content> and to reveal that arterial damage is irreversible despite rapid drug withdrawal. However, functional outcome was favorable upon rapid <jats:styled-content style=\"fixed-case\">TKI<\/jats:styled-content> replacement, specific cardiovascular disease management, and development of collateral arterial network.<\/jats:p>","DOI":"10.1111\/ejh.12367","type":"journal-article","created":{"date-parts":[[2014,5,3]],"date-time":"2014-05-03T16:03:12Z","timestamp":1399132992000},"page":"363-367","source":"Crossref","is-referenced-by-count":28,"title":["Rapid onset of peripheral artery disease in a chronic myeloid leukemia patient without prior arterial disorder: direct relationship with nilotinib exposure and clinical outcome"],"prefix":"10.1111","volume":"94","author":[{"given":"Tristan","family":"Mirault","sequence":"first","affiliation":[{"name":"M\u00e9decine Vasculaire H\u00f4pital Europ\u00e9en Georges\u2010Pompidou AP\u2010HP Paris France"},{"name":"Sorbonne Paris Cit\u00e9 Universit\u00e9 Paris Descartes Paris France"},{"name":"INSERM U970 PARCC Paris 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