{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:12:30Z","timestamp":1790082750300,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,5,26]],"date-time":"2014-05-26T00:00:00Z","timestamp":1401062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Invasive fungal diseases (<jats:styled-content style=\"fixed-case\">IFD<\/jats:styled-content>s) are an important cause of morbidity and mortality in patients undergoing allogeneic stem cell transplantation (<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To compare the effectiveness of two prophylactic antifungal regimens used as standard of care (<jats:styled-content style=\"fixed-case\">SOC<\/jats:styled-content>) in the setting of <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> during the periods of May 2006 \u2013 September 2009 (oral posaconazole, <jats:styled-content style=\"fixed-case\">POS<\/jats:styled-content>) and October 2009 \u2013 July 2011 (oral posaconazole with intravenous micafungin bridging, <jats:styled-content style=\"fixed-case\">POS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>), data from the Cologne Cohort of Neutropenic Patients (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ut) study were analyzed after nearest\u2010neighbor matching. Endpoints were occurrence of breakthrough probable\/proven <jats:styled-content style=\"fixed-case\">IFD<\/jats:styled-content> under prophylaxis, incidence and duration of persistent febrile neutropenia, incidence of unspecific pneumonic infiltrates, possible <jats:styled-content style=\"fixed-case\">IFD<\/jats:styled-content>, positive galactomannan tests, as well as fungal\u2010free and overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 291 patients with 307 <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>s observed during the study period, 212 fulfilled the inclusion criteria and were included into the analysis. Patients receiving <jats:styled-content style=\"fixed-case\">POS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content> were less likely to develop a pneumonic infiltrate (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 0.71, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.51\u20131.00) or possible <jats:styled-content style=\"fixed-case\">IFD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 0.36, 95% 0.15\u20130.87). They also demonstrated improved fungal\u2010free survival at day 100 (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.009). No significant differences were observed for the incidence of probable or proven <jats:styled-content style=\"fixed-case\">IFD<\/jats:styled-content>, positive galactomannan tests, persistent febrile neutropenia, duration of hospitalization and overall mortality. There was no grade <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">IV CTCAE<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ommon <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>erminology <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>riteria for <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>dverse <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>vents) toxicity related to antifungal prophylaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that both prophylactic regimens, <jats:styled-content style=\"fixed-case\">POS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">POS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content> are feasible, safe and effective. Our data suggest that bridging with intravenous micafungin could indeed improve exposure to antifungal prophylaxis, which may explain the reduced incidence of pneumonia and <jats:styled-content style=\"fixed-case\">IFD<\/jats:styled-content> in the bridging group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12368","type":"journal-article","created":{"date-parts":[[2014,5,3]],"date-time":"2014-05-03T16:03:17Z","timestamp":1399132997000},"page":"400-406","source":"Crossref","is-referenced-by-count":18,"title":["Feasibility and effectiveness of posaconazole prophylaxis in combination with micafungin bridging for patients undergoing allogeneic stem cell transplantation: A 6\u2010yr analysis from the cologne cohort for neutropenic patients"],"prefix":"10.1111","volume":"93","author":[{"given":"Maria J. G. T.","family":"Vehreschild","sequence":"first","affiliation":[{"name":"Klinik I f\u00fcr Innere Medizin Klinikum der Universit\u00e4t zu K\u00f6ln K\u00f6ln Germany"},{"name":"German Centre for Infection Research Partner site Bonn\u2010Cologne Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"von Bergwelt\u2010Baildon","sequence":"additional","affiliation":[{"name":"Klinik I f\u00fcr Innere Medizin Klinikum der Universit\u00e4t zu K\u00f6ln K\u00f6ln Germany"},{"name":"Stem Cell Transplantation Program Cologne Interventional Immunology Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliane","family":"Tran","sequence":"additional","affiliation":[{"name":"Klinik I f\u00fcr Innere Medizin Klinikum der Universit\u00e4t zu K\u00f6ln K\u00f6ln Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Shimabukuro\u2010Vornhagen","sequence":"additional","affiliation":[{"name":"Klinik I f\u00fcr Innere Medizin Klinikum der Universit\u00e4t zu K\u00f6ln K\u00f6ln Germany"},{"name":"Stem Cell Transplantation Program Cologne Interventional Immunology Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilmar","family":"Wisplinghoff","sequence":"additional","affiliation":[{"name":"Medizinische Mikrobiologie Immunologie und Hygiene Klinikum der Universit\u00e4t zu K\u00f6ln K\u00f6ln Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Bangard","sequence":"additional","affiliation":[{"name":"Institut und Poliklinik f\u00fcr Radiologische Diagnostik Klinikum der Universit\u00e4t zu K\u00f6ln K\u00f6ln Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver 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