{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T06:42:23Z","timestamp":1696401743436},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T00:00:00Z","timestamp":1403740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To assess the presence of genetic imbalances in patients with myeloproliferative neoplasms (MPNs), 38 patients with chronic eosinophilia were studied by array comparative genomic hybridization (<jats:styled-content style=\"fixed-case\">aCGH<\/jats:styled-content>): seven had chronic myelogenous leukaemia (CML), <jats:italic>BCR\u2010ABL1<\/jats:italic> positive, nine patients had myeloproliferative neoplasia Ph\u2212 (MPN\u2010Ph\u2212), three had a myeloid neoplasm associated with a <jats:italic>PDGFRA<\/jats:italic> rearrangement, and the remaining two cases were Lymphoproliferative T neoplasms associated with eosinophilia. In addition, 17 patients had a secondary eosinophilia and were used as controls. Eosinophilic enrichment was carried out in all cases. Genomic imbalances were found in 76% of all MPN patients. Losses on 20q were the most frequent genetic abnormality in MPNs (32%), affected the three types of MPN studied. This study also found losses at 11q13.3 in 26% of patients with MPN\u2010Ph\u2212 and in 19p13.11 in two of the three patients with an MPN associated with a <jats:italic>PDGFRA<\/jats:italic> rearrangement. In addition, 29% of patients with CML had losses on 8q24. In summary, <jats:styled-content style=\"fixed-case\">aCGH<\/jats:styled-content> revealed clonality in eosinophils in most MPNs, suggesting that it could be a useful technique for defining clonality in these diseases. The presence of genetic losses in new regions could provide new insights into the knowledge of these MPN associated with eosinophilia.<\/jats:p>","DOI":"10.1111\/ejh.12379","type":"journal-article","created":{"date-parts":[[2014,5,10]],"date-time":"2014-05-10T09:04:36Z","timestamp":1399712676000},"page":"422-428","source":"Crossref","is-referenced-by-count":1,"title":["Genomic analysis of clonal eosinophils by <scp>CGH<\/scp> arrays reveals new genetic regions involved in chronic eosinophilia"],"prefix":"10.1111","volume":"93","author":[{"given":"Maryam","family":"Arefi","sequence":"first","affiliation":[{"name":"Department of Hematology Hospital Cl\u00ednico Universitario Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Robledo","sequence":"additional","affiliation":[{"name":"IBSAL IBMCC Centre of Cancer Research Universidad de Salamanca\u2010CSIC Salamanca 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