{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:14:39Z","timestamp":1789719279519,"version":"4.0.1"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T00:00:00Z","timestamp":1417651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vascular events in essential thrombocythemia (<jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>) are associated with advanced age and thrombosis history. Recent information suggests additional effect from the presence of specific mutations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine the influence of age and thrombosis history on the reported association between mutational status and thrombosis\u2010free survival in <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Analysis was performed using a <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ayo <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>linic cohort of 300 <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> patients, and key findings were reanalyzed by including additional 102 Italian patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 300 Mayo patients with <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> (median age 55\u00a0yr, 60% females), mutational frequencies were 53% <jats:italic><jats:styled-content style=\"fixed-case\">JAK<\/jats:styled-content>2<\/jats:italic>, 32% <jats:italic><jats:styled-content style=\"fixed-case\">CALR<\/jats:styled-content><\/jats:italic>, 3% <jats:italic><jats:styled-content style=\"fixed-case\">MPL<\/jats:styled-content><\/jats:italic>, and 12% <jats:italic><jats:styled-content style=\"fixed-case\">JAK<\/jats:styled-content>2<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">CALR<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">MPL<\/jats:styled-content><\/jats:italic> wild type. One hundred and six (35%) patients experienced arterial (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>75) or venous (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>43) events, before (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>55) or after (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>71) diagnosis. In univariate analysis, compared to <jats:italic><jats:styled-content style=\"fixed-case\">JAK<\/jats:styled-content>2<\/jats:italic>\u2010mutated cases, <jats:italic><jats:styled-content style=\"fixed-case\">JAK<\/jats:styled-content>2<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">CALR<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">MPL<\/jats:styled-content><\/jats:italic> wild type (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 0.31, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.11\u20130.86), and <jats:italic><jats:styled-content style=\"fixed-case\">CALR<\/jats:styled-content><\/jats:italic>\u2010mutated (0.53, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.30\u20130.92) patients displayed better thrombosis\u2010free survival. <jats:italic><jats:styled-content style=\"fixed-case\">JAK<\/jats:styled-content>2<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">CALR<\/jats:styled-content>,<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">MPL<\/jats:styled-content><\/jats:italic> wild type remained significant (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03; <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 0.32, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.11\u20130.9) during multivariable analysis that included age (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01) and thrombosis history (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.0006); a favorable impact from <jats:italic><jats:styled-content style=\"fixed-case\">CALR<\/jats:styled-content><\/jats:italic> mutations was of borderline significance (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.1; <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 0.62, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.35\u20131.1), but became significant (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.02) when multivariable analysis including thrombosis history (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.02) was performed on patients younger than 60\u00a0yr of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The favorable impact of mutational status on thrombosis\u2010free survival in <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> might be most evident for <jats:italic><jats:styled-content style=\"fixed-case\">JAK<\/jats:styled-content>2<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">CALR<\/jats:styled-content>,<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">MPL<\/jats:styled-content><\/jats:italic> wild type patients, whereas the favorable effect from <jats:italic><jats:styled-content style=\"fixed-case\">CALR<\/jats:styled-content><\/jats:italic> mutations might be confined to young patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12389","type":"journal-article","created":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T06:42:46Z","timestamp":1401777766000},"page":"31-36","source":"Crossref","is-referenced-by-count":38,"title":["Mutations and thrombosis in essential thrombocythemia: prognostic interaction with age and thrombosis history"],"prefix":"10.1111","volume":"94","author":[{"given":"Naseema","family":"Gangat","sequence":"first","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emnet 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