{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:50:49Z","timestamp":1767340249486},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T00:00:00Z","timestamp":1404259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients receiving radiotherapy often experience toxicity of the skin and mucous membranes. While radiotherapy is a mainstay of myeloablative conditioning for allogeneic hematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">ASCT<\/jats:styled-content>), no risk factors for radiotoxicity have been identified in this setting. Here, we report on a patient with excessive radiation\u2010induced toxicity after <jats:styled-content style=\"fixed-case\">ASCT<\/jats:styled-content> who carried a heterozygous mutation in the <jats:italic>Ataxia telangiectasia mutated<\/jats:italic> (<jats:italic><jats:styled-content style=\"fixed-case\">ATM<\/jats:styled-content><\/jats:italic>) gene. This is the first case to suggest a genetic basis for increased radiotoxicity after myeloablative <jats:styled-content style=\"fixed-case\">ASCT<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ejh.12400","type":"journal-article","created":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T10:56:54Z","timestamp":1403002614000},"page":"90-92","source":"Crossref","is-referenced-by-count":7,"title":["Severe radiotoxicity in an allogeneic transplant recipient with a heterozygous <i><scp>ATM<\/scp><\/i> mutation"],"prefix":"10.1111","volume":"95","author":[{"given":"Benjamin N.","family":"Ostendorf","sequence":"first","affiliation":[{"name":"Department of Hematology, Oncology and Tumor Immunology Charit\u00e9 University Medicine Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theis H.","family":"Terwey","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Tumor Immunology Charit\u00e9 University Medicine Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp G.","family":"Hemmati","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Tumor Immunology Charit\u00e9 University Medicine Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"B\u00f6hmer","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Radiotherapy Charit\u00e9 University Medicine Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Pleyer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Charit\u00e9 University Medicine Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renate","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Tumor Immunology Charit\u00e9 University Medicine Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,2]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-037093"},{"key":"e_1_2_4_3_1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature11252","article-title":"Comprehensive molecular characterization of human colon and rectal cancer","volume":"487","author":"The Cancer Genome Atlas Network","year":"2013","journal-title":"Nature"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400874"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403221"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7792600"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/274484a0"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji141"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860500374513"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2010.05.002"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000301)88:5<1057::AID-CNCR16>3.0.CO;2-6"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12400","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T07:33:26Z","timestamp":1696404806000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,2]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/ejh.12400"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12400","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,2]]}}}