{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:32:25Z","timestamp":1791311545408,"version":"4.3.1"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,8,2]],"date-time":"2014-08-02T00:00:00Z","timestamp":1406937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Since the 1990s and since the development of humanised monoclonal antibodies in 1998, the treatment of non\u2010Hodgkin lymphoma has undergone profound changes. Follicular lymphoma (<jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>) was the first to benefit from this treatment, and several clinical trials have shown a significant improvement in overall survival, but little information is available at a population level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our objective was to estimate changes in <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>\u2010specific mortality at a population level, with an appropriate methodology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two French retrospective population\u2010based studies on <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> were conducted, one from 1995 to 2004, in 1477 patients, and one from 1995 to 2010, in 451 patients. Trends in excess mortality rates (<jats:styled-content style=\"fixed-case\">EMR<\/jats:styled-content>s) according to age, sex, Ann Arbor stage and year of diagnosis were evaluated using the flexible model of Remontet <jats:italic>et\u00a0al<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Trends in the <jats:styled-content style=\"fixed-case\">EMR<\/jats:styled-content> differed according to age at diagnosis and was higher in advanced stage (<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IV<\/jats:styled-content>) in patients older than 65\u00a0yr. The <jats:styled-content style=\"fixed-case\">EMR<\/jats:styled-content> decreased linearly from 1995 to 2010. This decrease was more marked for advanced stages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>\u2010specific mortality decreased over the years of diagnosis, and the difference according to the lymphoma stage diminished in more recent years. However, progress in the management of <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> was not able to erase age\u2010related differences.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12403","type":"journal-article","created":{"date-parts":[[2014,6,21]],"date-time":"2014-06-21T07:26:13Z","timestamp":1403335573000},"page":"120-129","source":"Crossref","is-referenced-by-count":12,"title":["Trends in excess mortality in follicular lymphoma at a population level"],"prefix":"10.1111","volume":"94","author":[{"given":"Morgane","family":"Mounier","sequence":"first","affiliation":[{"name":"Registre des H\u00e9mopathies Malignes de C\u00f4te d'Or EA 4184 Universit\u00e9 de Bourgogne Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Bossard","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon Lyon France"},{"name":"Universit\u00e9 Lyon 1 Villeurbanne France"},{"name":"CNRS UMR5558 Laboratoire de Biom\u00e9trie et Biologie Evolutive Equipe Biostatistique Sant\u00e9 Villeurbanne France"},{"name":"Service de Biostatistique Hospices Civils de Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Belot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon Lyon France"},{"name":"Universit\u00e9 Lyon 1 Villeurbanne France"},{"name":"CNRS UMR5558 Laboratoire de Biom\u00e9trie et Biologie Evolutive Equipe Biostatistique Sant\u00e9 Villeurbanne France"},{"name":"Service de Biostatistique Hospices Civils de Lyon Lyon France"},{"name":"D\u00e9partement des Maladies Chroniques et traumatismes Institut de Veille Sanitaire Saint Maurice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Remontet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon Lyon France"},{"name":"Universit\u00e9 Lyon 1 Villeurbanne France"},{"name":"CNRS UMR5558 Laboratoire de Biom\u00e9trie et Biologie Evolutive Equipe Biostatistique Sant\u00e9 Villeurbanne France"},{"name":"Service de Biostatistique Hospices Civils de Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Iwaz","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon Lyon France"},{"name":"Universit\u00e9 Lyon 1 Villeurbanne France"},{"name":"CNRS UMR5558 Laboratoire de Biom\u00e9trie et Biologie Evolutive Equipe Biostatistique Sant\u00e9 Villeurbanne France"},{"name":"Service de Biostatistique Hospices Civils de Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myl\u00e8ne","family":"Dandoit","sequence":"additional","affiliation":[{"name":"Registre des H\u00e9mopathies Malignes de C\u00f4te d'Or EA 4184 Universit\u00e9 de Bourgogne Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Girard\u2010Boulanger","sequence":"additional","affiliation":[{"name":"Registre des H\u00e9mopathies Malignes de C\u00f4te d'Or EA 4184 Universit\u00e9 de Bourgogne Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Herry","sequence":"additional","affiliation":[{"name":"Registre des H\u00e9mopathies Malignes de C\u00f4te d'Or EA 4184 Universit\u00e9 de Bourgogne Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Sophie","family":"Woronoff","sequence":"additional","affiliation":[{"name":"Registre des cancers du Doubs EA 3181 Centre Hospitalier Universitaire de Besan\u00e7on Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9\u2010Olivier","family":"Casasnovas","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Clinique Centre Hospitalier Universitaire de Dijon Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Maynadi\u00e9","sequence":"additional","affiliation":[{"name":"Registre des H\u00e9mopathies Malignes de C\u00f4te d'Or EA 4184 Universit\u00e9 de Bourgogne Dijon France"},{"name":"Service d'H\u00e9matologie Biologique Centre Hospitalier Universitaire de Dijon Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roch","family":"Giorgi","sequence":"additional","affiliation":[{"name":"UMR S912 Sciences Economiques &amp; 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