{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:58:35Z","timestamp":1776135515275,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T00:00:00Z","timestamp":1406764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The expression and activity of the uptake transporter human organic cation transporter 1 (hOCT1; <jats:styled-content style=\"fixed-case\">SLC<\/jats:styled-content>22A1) is an independent predictor of response to imatinib treatment in patients with chronic myeloid leukaemia (<jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>). We have recently shown that peroxisome proliferator\u2010activated receptor (<jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>) activation can increase the killing effect of imatinib in <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> cells, due to upregulated hOCT1 gene expression and increased imatinib uptake. To investigate the role of activation of nuclear receptors other than <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content> in the transcriptional regulation of <jats:italic>hOCT1<\/jats:italic>,<jats:styled-content style=\"fixed-case\"> CML<\/jats:styled-content> cells were treated with agonists for 13 adopted orphan receptors and endocrine receptors. It was found that <jats:italic>hOCT1<\/jats:italic> expression was upregulated by the agonists for pregnane X receptor (<jats:styled-content style=\"fixed-case\">PXR<\/jats:styled-content>), retinoid acid receptor (<jats:styled-content style=\"fixed-case\">RAR<\/jats:styled-content>) and retinoid X receptor (<jats:styled-content style=\"fixed-case\">RXR<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> cell line and primary <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> cells (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04; Wilcoxon rank test). Hence, agonists for <jats:styled-content style=\"fixed-case\">PXR<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> RAR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RXR<\/jats:styled-content> may be potentially used to improve the efficacy of imatinib in patients with <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ejh.12409","type":"journal-article","created":{"date-parts":[[2014,7,5]],"date-time":"2014-07-05T07:57:51Z","timestamp":1404547071000},"page":"74-78","source":"Crossref","is-referenced-by-count":15,"title":["Evidence that the pregnane <scp>X<\/scp> and retinoid receptors <scp>PXR<\/scp>,<scp> RAR<\/scp> and <scp>RXR<\/scp> may regulate transcription of the transporter <i>h<scp>OCT<\/scp>1<\/i> in chronic myeloid leukaemia cells"],"prefix":"10.1111","volume":"94","author":[{"given":"Gemma","family":"Austin","sequence":"first","affiliation":[{"name":"Section of Haematology Department of Molecular and Clinical Cancer Medicine University of Liverpool Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Holcroft","sequence":"additional","affiliation":[{"name":"Section of Haematology Department of Molecular and Clinical Cancer Medicine University of Liverpool Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha","family":"Rinne","sequence":"additional","affiliation":[{"name":"Section of Haematology Department of Molecular and Clinical Cancer Medicine University of Liverpool Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihui","family":"Wang","sequence":"additional","affiliation":[{"name":"Section of Haematology Department of Molecular and Clinical Cancer Medicine University of Liverpool Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard E.","family":"Clark","sequence":"additional","affiliation":[{"name":"Section of Haematology Department of Molecular and Clinical Cancer Medicine University of Liverpool Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,31]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2013.04.003"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-264234"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100268"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-093617"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.2160004"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2012.05.013"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4276"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.7.2444S"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.107.015842"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.05.020"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2010.266"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.033415"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2011.04.003"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2013.01.005"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2012.07.001"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200544090-00001"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V101.6.2368"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-003-0722-9"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4758"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12409","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:32:39Z","timestamp":1695501159000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,31]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/ejh.12409"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12409","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,31]]}}}