{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:51:46Z","timestamp":1788871906122,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T00:00:00Z","timestamp":1408665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"AIL (Associazione Italiana Leucemie), section of Sassari"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Although a number of studies suggest that different immune pathways may play a role in the pathogenesis of non\u2010Hodgkin's lymphomas (\n                    <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>\n                    ), the shape of the T\u2010cell compartment has been only superficially explored in these patients. In our study, we analyzed the peripheral T\u2010cell receptor (\n                    <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>\n                    ) repertoire and the distribution of different T\u2010cell subsets \u2013 including regulatory T cells (Treg) \u2013 in 30 patients with\n                    <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>\n                    , by combining flow cytometry and spectratyping. We first demonstrated by flow cytometry an increased frequency of expanded T\u2010cell subpopulations expressing the same\n                    <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>\n                    beta variable (BV) subfamilies in\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    8+ cells from\n                    <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>\n                    patients when compared with healthy controls, beside a higher frequency of Treg. Moreover,\n                    <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>\n                    patients were characterized by a higher percentage of\n                    <jats:styled-content style=\"fixed-case\">BV<\/jats:styled-content>\n                    s showing a skewed\n                    <jats:styled-content style=\"fixed-case\">CDR<\/jats:styled-content>\n                    3 profile both in\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    4+ and\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    8+ cells when analyzed by spectratyping. Our data suggest that the T\u2010cell branch of the immune system of patients with B\u2010cell\n                    <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>\n                    is deeply deranged, as witnessed by the increased degree of activation and skewing of their\n                    <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>\n                    repertoire along with the higher frequency of Treg.\n                  <\/jats:p>","DOI":"10.1111\/ejh.12417","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T13:44:23Z","timestamp":1405431863000},"page":"298-309","source":"Crossref","is-referenced-by-count":11,"title":["Derangement of the T\u2010cell repertoire in patients with B\u2010cell non\u2010Hodgkin's lymphoma"],"prefix":"10.1111","volume":"94","author":[{"given":"Claudio","family":"Fozza","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences University of Sassari 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