{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:59:15Z","timestamp":1788872355007,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T00:00:00Z","timestamp":1409702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"crossref","award":["GR-2010-2312984"],"award-info":[{"award-number":["GR-2010-2312984"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n \n PTEN<\/jats:styled-content>\n plays an essential role in the pathogenesis of chronic myeloid leukemia. Recently, we have shown that\n BCR<\/jats:styled-content>\n \u2010\n ABL<\/jats:styled-content>\n promotes\n PTEN<\/jats:styled-content>\n nuclear exclusion, through the modulation of\n HAUSP<\/jats:styled-content>\n activity.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n Here, we investigate\n HAUSP<\/jats:styled-content>\n cellular compartmentalization in primary\n CML<\/jats:styled-content>\n samples.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n While in normal\n CD<\/jats:styled-content>\n 34 positive cells\n HAUSP<\/jats:styled-content>\n is expressed mostly in the nucleus, in\n CML CD<\/jats:styled-content>\n 34 cells\n HAUSP<\/jats:styled-content>\n is expressed both in the nuclear bodies and in the cytoplasm.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This observation suggests that\n HAUSP<\/jats:styled-content>\n behaves as a shuttling protein in\n CML<\/jats:styled-content>\n . It can bind to\n BCR<\/jats:styled-content>\n \u2010\n ABL<\/jats:styled-content>\n in the cytosol, where it is phosphorylated on tyrosine residues, and it maintains the proper compartmentalization in the nuclear bodies, where it acts as part of a\n PML<\/jats:styled-content>\n network to regulate\n PTEN<\/jats:styled-content>\n de\u2010ubiquitination.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ejh.12422","type":"journal-article","created":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T03:47:56Z","timestamp":1406864876000},"page":"318-321","source":"Crossref","is-referenced-by-count":12,"title":["HAUSP<\/scp>\n compartmentalization in chronic myeloid leukemia"],"prefix":"10.1111","volume":"94","author":[{"given":"Alessandro","family":"Morotti","sequence":"first","affiliation":[{"name":"Department of Clinical and Biological Sciences University of Turin San Luigi Hospital Orbassano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Panuzzo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences University of Turin San Luigi Hospital Orbassano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Crivellaro","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences University of Turin San Luigi Hospital Orbassano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Carr\u00e0","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences University of Turin San Luigi Hospital Orbassano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Guerrasio","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences University of Turin San Luigi Hospital Orbassano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Saglio","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences University of Turin San Luigi Hospital Orbassano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2147"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1322.050"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2014.867323"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-228130"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.370"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.427"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-011-9185-5"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07290"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2009.173"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402126"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.01.021"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.4.1060-1072.2002"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.11.040"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1236188"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12422","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T03:36:51Z","timestamp":1696304211000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,3]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/ejh.12422"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12422","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,3]]}}}