{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T19:24:38Z","timestamp":1775071478119,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,9,13]],"date-time":"2014-09-13T00:00:00Z","timestamp":1410566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We randomised 46 newly diagnosed patients with chronic myeloid leukaemia (median age 56) to receive dasatinib 100\u00a0mg <jats:styled-content style=\"fixed-case\">QD<\/jats:styled-content> or imatinib 400\u00a0mg <jats:styled-content style=\"fixed-case\">QD<\/jats:styled-content> and report outcome as an intention\u2010to\u2010treat analysis with 36<jats:italic>\u00a0<\/jats:italic>months follow\u2010up. Early cytogenetic and molecular responses were superior in the dasatinib group, with a tendency that imatinib patients caught up with time. For instance, <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content><jats:sup>3.0<\/jats:sup> was reached at 3\u00a0months in 36% vs. 8% (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.02), at 12\u00a0months in 81% vs. 46% (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.02) and at 18\u00a0months in 73% vs. 65% (n.s.) of the patients in the two groups. In contrast, <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content><jats:sup>4.5<\/jats:sup> was consistently superior in the dasatinib group at all time points from 6\u00a0months onwards, reaching 61% vs. 21% (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05) at 36\u00a0months. Sixty\u2010four vs. 71% of the patients in the dasatinib and imatinib arms, respectively, remained on assigned drug. Dasatinib dose was frequently reduced, but with maintained excellent effect. One imatinib patient progressed to blastic phase, but no <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>\u2010related deaths occurred. In conclusion, our data compare favourably with those of the dasatinib registration study, <jats:styled-content style=\"fixed-case\">DASISION<\/jats:styled-content>. The fast and deep molecular responses induced by dasatinib compared with imatinib may be exploited to increase the proportion of patients who can achieve a treatment\u2010free remission after treatment discontinuation.<\/jats:p>","DOI":"10.1111\/ejh.12423","type":"journal-article","created":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T07:48:12Z","timestamp":1406879292000},"page":"243-250","source":"Crossref","is-referenced-by-count":51,"title":["Dasatinib induces fast and deep responses in newly diagnosed chronic myeloid leukaemia patients in chronic phase: clinical results from a randomised phase\u20102 study (<scp>N<\/scp>ord<scp>CML<\/scp>006)"],"prefix":"10.1111","volume":"94","author":[{"given":"Henrik","family":"Hjorth\u2010Hansen","sequence":"first","affiliation":[{"name":"Department of Hematology St Olavs Hospital Trondheim Norway"},{"name":"Department of Cancer Research and Molecular Medicine Norwegian University of Science and Technology (NTNU) Trondheim 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