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Between June 2011 and June 2012, one hundred patients with various haematological malignancies at risk for invasive fungal disease received primary antifungal prophylaxis with intravenous micafungin at a daily dosage of 50\u00a0mg during neutropenia. The median number of days on micafungin prophylaxis was 14 (range, 6\u201348\u00a0d). The incidence of proven and probable breakthrough invasive fungal diseases (<jats:styled-content style=\"fixed-case\">bIFD<\/jats:styled-content>s) was 6% and 3%, respectively. There were two bloodstream infections caused by yeasts or yeast\u2010like fungi (<jats:italic>Candida krusei<\/jats:italic>,<jats:italic> Trichosporon asahii<\/jats:italic>) in two patients during the neutropenic phase after allogeneic haematopoietic stem cell transplantation. Four proven <jats:styled-content style=\"fixed-case\">bIFD<\/jats:styled-content>s caused by non\u2010<jats:italic>Aspergillus<\/jats:italic> moulds and three cases of probable pulmonary <jats:styled-content style=\"fixed-case\">bIFD<\/jats:styled-content>s were documented during the neutropenic phase after induction\/consolidation chemotherapy for acute leukaemia. Colonisation with <jats:italic>Candida<\/jats:italic> spp. was documented in 51% of the patients with none of the isolates being <jats:italic>in vitro<\/jats:italic> micafungin resistant. Compared to a historical control, receiving primary prophylaxis with posaconazole micafungin is at least as effective in preventing IFD. In both cohorts, <jats:styled-content style=\"fixed-case\">bIFD<\/jats:styled-content>s were exclusively caused by emerging pathogens with a highly preserved <jats:italic>in vitro<\/jats:italic> sensitivity to amphotericin B.<\/jats:p>","DOI":"10.1111\/ejh.12426","type":"journal-article","created":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T07:48:18Z","timestamp":1406879298000},"page":"258-264","source":"Crossref","is-referenced-by-count":37,"title":["Primary antifungal prophylaxis with micafungin in patients with haematological malignancies: real\u2010life data from a retrospective single\u2010centre observational study"],"prefix":"10.1111","volume":"94","author":[{"given":"David","family":"Nachbaur","sequence":"first","affiliation":[{"name":"Haematology &amp; Oncology University Hospital of Internal Medicine V Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Angelova","sequence":"additional","affiliation":[{"name":"Haematology &amp; Oncology University Hospital of Internal Medicine V Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothea","family":"Orth\u2010H\u00f6ller","sequence":"additional","affiliation":[{"name":"Division of Hygiene and Medical Microbiology Medical University Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelheid","family":"Ditlbacher","sequence":"additional","affiliation":[{"name":"Haematology &amp; Oncology University Hospital of Internal Medicine V Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Lackner","sequence":"additional","affiliation":[{"name":"Division of Hygiene and Medical Microbiology Medical University Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutta","family":"Auberger","sequence":"additional","affiliation":[{"name":"Haematology &amp; Oncology University Hospital of Internal Medicine V Innsbruck Austria"},{"name":"3rd Medical Department with Hematology, Medical Oncology, Hemostaseology, Rheumatology, and Infectious Diseases Paracelsus Private Medical University Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Lass\u2010Fl\u00f6rl","sequence":"additional","affiliation":[{"name":"Division of Hygiene and Medical Microbiology Medical University Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.175"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.147"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq147"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11665"},{"key":"e_1_2_7_6_1","unstructured":"National Comprehensive Cancer Network.NCCN Clinical Practice Guidelines in Oncology: Prevention and Treatment of Cancer\u2010Related Infections. 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