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These cells, which naturally play a role in the innate, non\u2010specific immune response, develop from thymic precursor in the bone marrow, lack the major histocompatibility complex restrictions and can be divided into two subpopulations: Vdelta1, mostly represented in the intestine, and Vdelta2, prevalently located in the skin, tonsils and lymph nodes. Chronic immunosuppression such as in solid organ transplanted subjects and prolonged antigenic exposure are probably the strongest risk factors for the triggering of lymphomagenesis. Two entities are recognised by the 2008 <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> Classification: hepatosplenic gamma\u2010delta T\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">HSGDTL<\/jats:styled-content>) and primary cutaneous gamma\u2010delta T\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">PCGDTL<\/jats:styled-content>). The former is more common among young males, presenting with B symptoms, splenomegaly and thrombocytopenia, usually with the absence of nodal involvement. Natural behaviour of <jats:styled-content style=\"fixed-case\">HSGDTL<\/jats:styled-content> is characterised by low response rates, poor treatment tolerability, common early progression of disease and disappointing survival figures. <jats:styled-content style=\"fixed-case\">PCGDTL<\/jats:styled-content> accounts for &lt;1% of all primary cutaneous lymphomas, occurring in adults with relevant comorbidities. Cutaneous lesions may vary, but its clinical behaviour is usually aggressive and long\u2010term survival is anecdotal. Available literature on gamma\u2010delta T\u2010cell lymphomas is fractioned, mostly consisting of case reports or small cumulative series. Therefore, clinical suspicion and diagnosis are usually delayed, and therapeutic management remains to be established. This review critically analyses available evidence on diagnosis, staging and behaviour of gamma\u2010delta T\u2010cell lymphomas, provides recommendations for therapeutic management in routine practice and discusses relevant unmet clinical needs for future studies.<\/jats:p>","DOI":"10.1111\/ejh.12439","type":"journal-article","created":{"date-parts":[[2014,8,23]],"date-time":"2014-08-23T14:17:16Z","timestamp":1408803436000},"page":"206-218","source":"Crossref","is-referenced-by-count":77,"title":["Gamma\u2010delta t\u2010cell lymphomas"],"prefix":"10.1111","volume":"94","author":[{"given":"Marco","family":"Foppoli","sequence":"first","affiliation":[{"name":"Unit of Lymphoid Malignancies Division of Onco\u2010Hematological Medicine Department of Onco\u2010Hematology San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s J. 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