{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:13:16Z","timestamp":1790359996745,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CNPq\/FAPESP","award":["2008\/57895-1"],"award-info":[{"award-number":["2008\/57895-1"]}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2012\/09982-8"],"award-info":[{"award-number":["2012\/09982-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2011\/15905-3"],"award-info":[{"award-number":["2011\/15905-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2011\/51959-0"],"award-info":[{"award-number":["2011\/51959-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>TET2<\/jats:italic>, a member of the ten\u2010eleven\u2010translocation (TET) family genes that modify DNA by converting 5\u2010methylcytosine (5\u2010<jats:styled-content style=\"fixed-case\">mC<\/jats:styled-content>) to 5\u2010hydroxymethylcytosine (5\u2010hmC), is located in chromosome 4q24 and is frequently mutated in myeloid malignancies. The impact of <jats:italic>TET2<\/jats:italic> mutation on survival outcomes is still controversial; however, functional studies have proved that it is a loss\u2010of\u2010function mutation that impairs myeloid cell differentiation and contributes to the phenotype of myeloid neoplasia. We, herein, aimed to investigate <jats:italic>TET2<\/jats:italic> expression in patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). A significantly decreased <jats:italic>TET2<\/jats:italic> expression was observed in bone marrow cells from AML (<jats:italic>n<\/jats:italic>\u00a0=\u00a053) and patients with MDS (<jats:italic>n<\/jats:italic>\u00a0=\u00a064), compared to normal donors (<jats:italic>n<\/jats:italic>\u00a0=\u00a022). In MDS, <jats:italic>TET2<\/jats:italic> expression was significantly reduced in RAEB\u20101\/RAEB\u20102 compared to other WHO 2008 classifications, and a lower <jats:italic>TET2<\/jats:italic> expression was observed at the time of MDS disease progression in four of five patients. In multivariate analysis, low <jats:italic>TET2<\/jats:italic> expression (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03), male gender (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.02), and WHO 2008 classification (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001) were independent predictors of poorer overall survival. These results suggest that defective <jats:italic>TET2<\/jats:italic> expression plays a role in the MDS pathophysiology and predicts survival outcomes in this disease.<\/jats:p>","DOI":"10.1111\/ejh.12445","type":"journal-article","created":{"date-parts":[[2014,9,8]],"date-time":"2014-09-08T16:53:10Z","timestamp":1410195190000},"page":"413-418","source":"Crossref","is-referenced-by-count":19,"title":["Ten\u2010Eleven\u2010Translocation 2 (<scp>TET<\/scp>2) is downregulated in myelodysplastic syndromes"],"prefix":"10.1111","volume":"94","author":[{"given":"Renata","family":"Scopim\u2010Ribeiro","sequence":"first","affiliation":[{"name":"Hematology and Hemotherapy Center\u2010University of Campinas\/Hemocentro\u2010Unicamp Instituto Nacional de Ci\u00eancia e Tecnologia do Sangue Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Agostinho","family":"Machado\u2010Neto","sequence":"additional","affiliation":[{"name":"Hematology and Hemotherapy Center\u2010University of Campinas\/Hemocentro\u2010Unicamp Instituto Nacional de Ci\u00eancia e Tecnologia do Sangue Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula de Melo","family":"Campos","sequence":"additional","affiliation":[{"name":"Hematology and Hemotherapy Center\u2010University of Campinas\/Hemocentro\u2010Unicamp Instituto Nacional de Ci\u00eancia e Tecnologia do Sangue Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleide Aparecida Moreira","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Statistical Nucleus, Research Commission School of Medical Sciences University of Campinas Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Favaro","sequence":"additional","affiliation":[{"name":"Hematology and Hemotherapy Center\u2010University of Campinas\/Hemocentro\u2010Unicamp Instituto Nacional de Ci\u00eancia e Tecnologia do Sangue Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Lorand\u2010Metze","sequence":"additional","affiliation":[{"name":"Hematology and Hemotherapy Center\u2010University of Campinas\/Hemocentro\u2010Unicamp Instituto Nacional de Ci\u00eancia e Tecnologia do Sangue Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Ferreira","family":"Costa","sequence":"additional","affiliation":[{"name":"Hematology and Hemotherapy Center\u2010University of Campinas\/Hemocentro\u2010Unicamp Instituto Nacional de Ci\u00eancia e Tecnologia do Sangue Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Teresinha Olalla","family":"Saad","sequence":"additional","affiliation":[{"name":"Hematology and Hemotherapy Center\u2010University of Campinas\/Hemocentro\u2010Unicamp Instituto Nacional de Ci\u00eancia e Tecnologia do Sangue Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Traina","sequence":"additional","affiliation":[{"name":"Hematology and Hemotherapy Center\u2010University of Campinas\/Hemocentro\u2010Unicamp Instituto Nacional de Ci\u00eancia e Tecnologia do Sangue Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810069"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-205690"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.59"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.06.001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-325241"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.391"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-215814"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-210039"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09586"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-324707"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-420489"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.7.2322"},{"key":"e_1_2_7_14_1","first-page":"87","volume-title":"WHO 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