{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T01:39:39Z","timestamp":1789781979687,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,7]],"date-time":"2015-01-07T00:00:00Z","timestamp":1420588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008363","name":"Danish Cancer Society","doi-asserted-by":"crossref","award":["R2-A310-09-S2"],"award-info":[{"award-number":["R2-A310-09-S2"]}],"id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Syndecan\u20101 (<jats:styled-content style=\"fixed-case\">SDC<\/jats:styled-content>1), hepatocyte growth factor (<jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content>), vascular endothelial growth factor (<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>) and interleukin\u20106 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>6) are expressed by malignant plasma cells and cells in the bone marrow microenvironment and may be involved in the angiogenic process in multiple myeloma (<jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we examined the association between bone marrow angiogenesis estimated as micro\u2010vessel density (<jats:styled-content style=\"fixed-case\">MVD<\/jats:styled-content>) and gene expression of <jats:italic><jats:styled-content style=\"fixed-case\">SDC<\/jats:styled-content>1<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content><\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>6<\/jats:italic> in whole bone marrow biopsies from healthy volunteers (<jats:italic>n<\/jats:italic>\u00a0=\u00a010), patients with monoclonal gammopathy of undetermined significance (<jats:styled-content style=\"fixed-case\">MGUS<\/jats:styled-content>) (<jats:italic>n<\/jats:italic>\u00a0=\u00a035) and <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a065).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MVD<\/jats:styled-content> was significantly higher in patients with <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> than <jats:styled-content style=\"fixed-case\">MGUS<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.03) and was positively correlated with plasma cell percentage (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.002). <jats:italic><jats:styled-content style=\"fixed-case\">SDC<\/jats:styled-content>1<\/jats:italic> gene expression increased with increasing <jats:styled-content style=\"fixed-case\">MVD<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">MGUS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). A positive correlation between bone marrow plasma cell percentage and <jats:italic><jats:styled-content style=\"fixed-case\">SDC<\/jats:styled-content>1<\/jats:italic> gene expression was detected in patients with <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). Importantly, after adjustment for plasma cell percentage, the association between <jats:styled-content style=\"fixed-case\">MVD<\/jats:styled-content> and <jats:italic><jats:styled-content style=\"fixed-case\">SDC<\/jats:styled-content>1<\/jats:italic> gene expression remained significant (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.026). No association between bone marrow angiogenesis and gene expression of <jats:italic><jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content><\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>6<\/jats:italic> was seen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study indicates that <jats:styled-content style=\"fixed-case\">SDC<\/jats:styled-content>1 expressed by the bone marrow microenvironment is involved in angiogenesis in <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12473","type":"journal-article","created":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T12:55:21Z","timestamp":1414587321000},"page":"211-217","source":"Crossref","is-referenced-by-count":14,"title":["Upregulation of Syndecan\u20101 in the bone marrow 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