{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T04:00:53Z","timestamp":1774497653156,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T00:00:00Z","timestamp":1423008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grants\u00e2\u20ac\u0090in\u00e2\u20ac\u0090aid for Scientific Research from theMinistry of Education, Culture, Sports, Science and Technology","award":["24390243"],"award-info":[{"award-number":["24390243"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Trisomy 8 (+8), one of the most common chromosomal abnormalities found in patients with myelodysplastic syndromes (<jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>), is occasionally seen in patients with otherwise typical aplastic anemia (<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>). Although some studies have indicated that the presence of +8 is associated with the immune pathophysiology of bone marrow (<jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content>) failure, its pathophysiology may be heterogeneous. We studied 53 patients (22 with AA and 31 with low\u2010risk <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>) with +8 for the presence of increased glycosylphosphatidylinositol\u2010anchored protein\u2010deficient (<jats:styled-content style=\"fixed-case\">GPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content><jats:sup>\u2212<\/jats:sup>) cells, their response to immunosuppressive therapy (<jats:styled-content style=\"fixed-case\">IST<\/jats:styled-content>), and their prognosis. A significant increase in the percentage of <jats:styled-content style=\"fixed-case\">GPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content><jats:sup>\u2212<\/jats:sup> cells was found in 14 (26%) of the 53 patients. Of the 26 patients who received <jats:styled-content style=\"fixed-case\">IST<\/jats:styled-content>, including nine with increased <jats:styled-content style=\"fixed-case\">GPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content><jats:sup>\u2212<\/jats:sup> cells and 17 without increased <jats:styled-content style=\"fixed-case\">GPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content><jats:sup>\u2212<\/jats:sup> cells, 14 (88% with increased <jats:styled-content style=\"fixed-case\">GPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content><jats:sup>\u2212<\/jats:sup> cells and 41% without increased <jats:styled-content style=\"fixed-case\">GPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content><jats:sup>\u2212<\/jats:sup> cells) improved. The overall and event\u2010free survival rates of the +8 patients with and without increased <jats:styled-content style=\"fixed-case\">GPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content><jats:sup>\u2212<\/jats:sup> cells at 5\u00a0yr were 100% and 100% and 59% and 57%, respectively. Examining the peripheral blood for the presence of increased <jats:styled-content style=\"fixed-case\">GPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content><jats:sup>\u2212<\/jats:sup> cells may thus be helpful for choosing the optimal treatment for +8 patients with <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> or low\u2010risk <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ejh.12484","type":"journal-article","created":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T11:00:35Z","timestamp":1416308435000},"page":"230-238","source":"Crossref","is-referenced-by-count":18,"title":["Increased glycosylphosphatidylinositol\u2010anchored protein\u2010deficient granulocytes define a benign subset of bone marrow failures in patients with trisomy 8"],"prefix":"10.1111","volume":"95","author":[{"given":"Kohei","family":"Hosokawa","sequence":"first","affiliation":[{"name":"Cellular Transplantation Biology Kanazawa University Graduate School of Medical Science Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Sugimori","sequence":"additional","affiliation":[{"name":"Cellular Transplantation Biology Kanazawa University Graduate School of Medical Science Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takamasa","family":"Katagiri","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Science Kanazawa University Graduate School of Medical Science Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Cellular Transplantation Biology Kanazawa University Graduate School of Medical Science Kanazawa 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