{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:40:55Z","timestamp":1762875655976},"reference-count":33,"publisher":"Wiley","issue":"s77","license":[{"start":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T00:00:00Z","timestamp":1420416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Haemophilia prophylaxis is superior to on\u2010demand treatment to prevent joint damage. \u2018High\u2010dose prophylaxis\u2019 as used in Sweden is more effective in preventing arthropathy than an \u2018intermediate\u2010dose regimen\u2019 (the Netherlands) and the Canadian tailored primary prophylaxis. Prophylaxis may reduce the risk of developing inhibitors. There is no difference in inhibitor risk between plasma derived and recombinant factor VIII (<jats:styled-content style=\"fixed-case\">rFVIII<\/jats:styled-content>) products but the Rodin study showed increased risk with second\u2010generation <jats:styled-content style=\"fixed-case\">rFVIII<\/jats:styled-content> products. <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> is a new and very sensitive tool to detect the symptoms of early arthropathy but some results (soft tissue changes in \u2018bleed\u2010free joints\u2019) still need to be investigated. Ultrasound is a very helpful method to aid diagnosis especially during the acute phase of a bleed. The risk of infection with central venous access remains a matter of debate. A fully implanted central venous access device (<jats:styled-content style=\"fixed-case\">CVAD<\/jats:styled-content>) has a significant lower risk of infection compared to external <jats:styled-content style=\"fixed-case\">CVAD<\/jats:styled-content>s. Patient's age under 6\u00a0yr and inhibitor presence are additional risk factors for infections. The role of arteriovenous fistulae needs to be investigated because significant complications have been reported. Disease\u2010specific quality of life instruments are complementary to generic instruments evaluating QoL in patients with haemophilia and have become important health outcome measures.<\/jats:p>","DOI":"10.1111\/ejh.12496","type":"journal-article","created":{"date-parts":[[2015,1,6]],"date-time":"2015-01-06T05:55:16Z","timestamp":1420523716000},"page":"11-16","source":"Crossref","is-referenced-by-count":7,"title":["Various regimens for prophylactic treatment of patients with haemophilia"],"prefix":"10.1111","volume":"94","author":[{"given":"Rudolf","family":"Schwarz","sequence":"first","affiliation":[{"name":"Childrens and Maternity Hospital Linz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Ljung","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund \u2013 Paediatrics Lund University Hospital Sk\u00e5ne University Hospital Malm\u00f6 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