{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T07:03:43Z","timestamp":1781507023257,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"s77","license":[{"start":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T00:00:00Z","timestamp":1420416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Older patients with haemophilia (<jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content>) face many challenges related not only to haemophilia but also to general comorbidities associated with ageing. This article discusses the clinical experience published about the high prevalence of diseases in older <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content>. These conditions are managed in the general population by healthcare workers with little training in haemophilia. Haemophilic arthropathy is common in elderly <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content>. Prophylaxis starting at an early age in sufficient dose regimens to prevent arthropathy did not occur in patients who are now older than around 40\u00a0yr. Many <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content> above this age thus have limitations in their activities of daily life. Cardiovascular diseases have become increasingly common in the growing, ageing cohort of <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content>. Lifestyle issues such as sexual dysfunction may be exacerbated by the medical issues and psychological problems associated with haemophilia. Hepatitis C virus is a leading problem in <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content>. Coinfection with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> accelerates the progression to end\u2010stage liver disease. Acute and chronic renal failure is more common in adult <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content> than in general population. Other comorbidities are reviewed. The evidence is scarce, so it is imperative to report any experience regarding the diagnosis and treatment of these entities, to improve the quality of life of older <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ejh.12497","type":"journal-article","created":{"date-parts":[[2015,1,6]],"date-time":"2015-01-06T05:55:16Z","timestamp":1420523716000},"page":"17-22","source":"Crossref","is-referenced-by-count":28,"title":["The ageing patient with haemophilia"],"prefix":"10.1111","volume":"94","author":[{"given":"Mariana","family":"Canaro","sequence":"first","affiliation":[{"name":"Thrombosis and Haemostasis Unit Son Espases University Hospital Palma de Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veselina","family":"Goranova\u2010Marinova","sequence":"additional","affiliation":[{"name":"Clinic of Hematology University Hospital \u2018Sv.Georgi\u2019 Plovdiv 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