{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:29:14Z","timestamp":1792517354762,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,23]],"date-time":"2015-03-23T00:00:00Z","timestamp":1427068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to evaluate bone involvement in patients with Gaucher disease (<jats:styled-content style=\"fixed-case\">GD<\/jats:styled-content>) and to propose a novel semi\u2010quantitative magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) staging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MRI of the lumbar spine, femur, and tibia was performed in 24 patients with <jats:styled-content style=\"fixed-case\">GD<\/jats:styled-content> and 24 healthy controls. We also measured circulating levels of <jats:styled-content style=\"fixed-case\">C\u2010C<\/jats:styled-content> motif ligand\u20103 (<jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>\u20103) chemokine, C\u2010telopeptide of collagen type\u20101 (<jats:styled-content style=\"fixed-case\">CTX<\/jats:styled-content>), and tartrate\u2010resistant acid phosphatase isoform type\u2010b (<jats:styled-content style=\"fixed-case\">TRACP<\/jats:styled-content>\u20105b).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We used the following staging based on <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> data: stage I: region of interest (<jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content>) 1\/2 of normal values and bone infiltration up to 30%; stage II: <jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content> 1\/3 of normal values and bone infiltration from 30 to 60%; stage III: <jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content> 1\/4 of normal values and bone infiltration from 60% to 80%; and stage IV: detection of epiphyseal infiltration, osteonecrosis and deformity regardless of the <jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content>'s values. All but two patients had abnormal <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> findings: 9 (37.5%), 6 (25%), 3 (12.5%), and 4 (16.7%) had stages I\u2013IV, respectively. Patients with <jats:styled-content style=\"fixed-case\">GD<\/jats:styled-content> had elevated chitotriosidase, serum <jats:styled-content style=\"fixed-case\">TRACP<\/jats:styled-content>\u20105b, and <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>\u20103 levels (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We propose an easily reproducible semi\u2010quantitative scoring system and confirm that patients with <jats:styled-content style=\"fixed-case\">GD<\/jats:styled-content> have abnormal <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> bone findings and enhanced osteoclast activity possibly due to elevated <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>\u20103.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12504","type":"journal-article","created":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T10:26:14Z","timestamp":1421749574000},"page":"342-351","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of bone involvement in patients with Gaucher disease: a semi\u2010quantitative magnetic resonance imaging method (using ROI estimation of bone lesion) as an alternative method to semi\u2010quantitative methods used so far"],"prefix":"10.1111","volume":"95","author":[{"given":"Veroniki","family":"Komninaka","sequence":"first","affiliation":[{"name":"Thalassaemia Centre Laikon General Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dionysia","family":"Kolomodi","sequence":"additional","affiliation":[{"name":"Department of Radiology Laikon General Hospital Athens 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