{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T19:17:03Z","timestamp":1772565423081,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T00:00:00Z","timestamp":1431907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Most central venous catheter (<jats:styled-content style=\"fixed-case\">CVC<\/jats:styled-content>)\u2010related deep vein thromboses (<jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content>) are asymptomatic and their incidence and clinical relevance are still under debate. Data on <jats:styled-content style=\"fixed-case\">CVC<\/jats:styled-content>\u2010related fibrin sheaths are scarce. We investigated the incidence of asymptomatic <jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content> and fibrin sheaths in cancer patients with long\u2010term <jats:styled-content style=\"fixed-case\">CVC<\/jats:styled-content> implantation who underwent Doppler ultrasound surveillance at 1, 6, and 12\u00a0months after implantation. Effects of low\u2010weight molecular heparin (<jats:styled-content style=\"fixed-case\">LWMH<\/jats:styled-content>) therapy on <jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content> and fibrin sheaths were also analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>This prospective study was performed on a large cohort (<jats:italic>n<\/jats:italic>\u00a0=\u00a0400) of patients with cancer aged &gt;18 requiring long\u2010term <jats:styled-content style=\"fixed-case\">CVC<\/jats:styled-content> implantation for chemotherapy infusion. <jats:styled-content style=\"fixed-case\">CVC<\/jats:styled-content> was implanted by a trained qualified staff, according to standardized protocol in a specific surgery. Patients underwent ultrasound examination at 1 and 6\u00a0months after <jats:styled-content style=\"fixed-case\">CVC<\/jats:styled-content> implantation to detect \u2018early\u2019 (1\u00a0month) and \u2018late\u2019 (6\u00a0months) asymptomatic <jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content> or fibrin sheaths incidence. Sixty\u2010nine patients underwent <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> examination also 12\u00a0months after <jats:styled-content style=\"fixed-case\">CVC<\/jats:styled-content> implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of <jats:styled-content style=\"fixed-case\">CVC<\/jats:styled-content>\u2010related thrombosis was 0.10 events per 1000\u00a0catheter days. Anticoagulation therapy with <jats:styled-content style=\"fixed-case\">LWMH<\/jats:styled-content> resolved 50% of <jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content>, but no <jats:styled-content style=\"fixed-case\">CVC<\/jats:styled-content> needed removing. Incidence of new onset fibrin sheaths was 0.71 events per 1000\u00a0catheter days. Fibrin sheaths resolution occurred independently of <jats:styled-content style=\"fixed-case\">LWMH<\/jats:styled-content> therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The incidence of asymptomatic <jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content> in our patients with long\u2010term <jats:styled-content style=\"fixed-case\">CVC<\/jats:styled-content> is very low and does not represent per se an indication for removal of functioning <jats:styled-content style=\"fixed-case\">CVC<\/jats:styled-content> in patients with cancer. Fibrin sheaths are frequent (13%) and never associated with <jats:styled-content style=\"fixed-case\">CVC<\/jats:styled-content> dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Asymptomatic DVT and fibrin sheaths do not represent per se an indication for removal of functioning CVC in cancer patients who need central vein access.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12519","type":"journal-article","created":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T03:03:31Z","timestamp":1421636611000},"page":"472-479","source":"Crossref","is-referenced-by-count":23,"title":["Incidence of ultrasound\u2010detected asymptomatic long\u2010term central vein catheter\u2010related thrombosis and fibrin sheath in cancer patients"],"prefix":"10.1111","volume":"95","author":[{"given":"Maria","family":"Boddi","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Medicine Careggi Teaching Hospital Florence 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