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However, little is known about the effect of <jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content>\u2010F on the reconstitution of B\u2010cell subsets. Sixty\u2010seven patients were longitudinally studied at day 15, day 30, and then monthly after hematopoietic stem cell transplantation. Conditioning regimes included <jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content>\u2010F, which was infused at days 3, 2 and 1 at a dosage of 10\u00a0mg\/kg\/d. Twenty\u2010seven patients received conditioning regimes without <jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content>\u2010treated patients showed a significant delay of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>19+ B cells in the early recovery period. The absolute numbers of circulating <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>19+ B cells were significantly lower (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05) up to 5\u00a0months post\u2010transplantation compared to non\u2010<jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content> patients. The recovery of the memory compartment was delayed in both groups and did not reach normal values 1\u2010year post\u2010transplantation. <jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content>\u2010treated patient showed significantly lower absolute numbers of circulating <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>27+ memory B cells in the first\u2010month after transplantation compared to non\u2010<jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content> patients. In conclusion, treatment with <jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content> in the conditioning regime of patients undergoing allogeneic hematopoietic stem cell transplantation leads to a significant delay of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>19+ B cells. Thus, <jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content> seems also to negatively influence B\u2010cell immune reconstitution.<\/jats:p>","DOI":"10.1111\/ejh.12524","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T10:44:52Z","timestamp":1423824292000},"page":"514-523","source":"Crossref","is-referenced-by-count":17,"title":["Effect of ATG\u2010F on B\u2010cell reconstitution after hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"95","author":[{"given":"Petra","family":"Roll","sequence":"first","affiliation":[{"name":"Department of Medicine II University of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Muhammad","sequence":"additional","affiliation":[{"name":"Department of Medicine II University of W\u00fcrzburg W\u00fcrzburg 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