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Ten patients were enrolled and all completed the 12\u2010month treatment period. There were significant decreases from baseline to end of study (i.e., 12\u00a0months) in median serum ferritin (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), mean transferrin saturation (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), median liver iron concentration (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and mean alanine aminotransferase (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The median time to achieve serum ferritin reduction \u226550% compared to baseline was 7.53\u00a0months. The most common adverse events were mild, transient diarrhea (<jats:italic>n<\/jats:italic>\u00a0=\u00a05) and nausea (<jats:italic>n<\/jats:italic>\u00a0=\u00a02). No patient experienced an increase in serum creatinine that exceeded the upper limit of normal. These data confirm that deferasirox was well tolerated and effective in reducing iron burden in patients with hereditary hemochromatosis and could be a safe alternative to phlebotomy in selected patients.<\/jats:p>","DOI":"10.1111\/ejh.12530","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T13:10:09Z","timestamp":1423833009000},"page":"545-550","source":"Crossref","is-referenced-by-count":46,"title":["Deferasirox in patients with iron overload secondary to hereditary hemochromatosis: results of a 1\u2010yr Phase 2 study"],"prefix":"10.1111","volume":"95","author":[{"given":"Rodolfo","family":"Can\u00e7ado","sequence":"first","affiliation":[{"name":"Department of Hematology\/Oncology Santa Casa Medical School Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murilo R.","family":"Melo","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory Santa Casa Medical School Sao Paolo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"de Moraes Bastos","sequence":"additional","affiliation":[{"name":"Radiology Department Santa Casa Medical School Sao Paolo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo C. 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