{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T07:48:26Z","timestamp":1696405706743},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T00:00:00Z","timestamp":1426464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>After hematopoietic stem cell transplantation, invasive aspergillosis remains one of the most lethal infections. Susceptibility may be due to prophylaxis and treatment of graft\u2010vs.\u2010host disease in T\u2010cell\u2010replete transplants, and delayed immune rebuilding due to T\u2010cell depletion in haploidentical transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We monitored <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T\u2010cell recovery and anti\u2010<jats:italic>Aspergillus<\/jats:italic> immune competence in pediatric recipients of T\u2010cell\u2010replete matched transplants and of prevalently adult recipients of T\u2010cell\u2010depleted matched or haploidentical transplants for hematological malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T\u2010cell counts were higher in T\u2010cell\u2010replete transplant recipients at all post\u2010transplant time points, <jats:italic>Aspergillus<\/jats:italic>\u2010specific T cells were first detected 15\u201318\u00a0months after T\u2010cell\u2010replete matched, 7\u20139\u00a0months after T\u2010cell\u2010depleted matched, and 9\u201312\u00a0months after haploidentical transplantation, respectively. Incidence of invasive aspergillosis was 22% with 10% mortality after T\u2010cell\u2010replete transplants, 0% after T\u2010cell\u2010depleted matched, and 7% with 4% mortality after haploidentical transplants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although T\u2010cell counts were significantly higher after T\u2010cell\u2010replete transplants, post\u2010transplant immune suppression\/Gv<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> appeared to impair their function. Specific <jats:italic>Aspergillus<\/jats:italic> immune competence recovered faster after T\u2010cell\u2010depleted transplants, whether matched or haploidentical. T\u2010cell\u2010replete transplants were associated with a higher incidence of invasive aspergillosis and <jats:italic>Aspergillus<\/jats:italic>\u2010related deaths. These results showed that T\u2010cell depletion without post\u2010transplant immunosuppression is associated to a faster immune recovery than T\u2010cell\u2010replete transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12531","type":"journal-article","created":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T15:46:45Z","timestamp":1424101605000},"page":"551-557","source":"Crossref","is-referenced-by-count":4,"title":["Differences in <i>Aspergillus\u2010<\/i>specific immune recovery between T\u2010cell\u2010replete and T\u2010cell\u2010depleted hematopoietic transplants"],"prefix":"10.1111","volume":"95","author":[{"given":"Katia","family":"Perruccio","sequence":"first","affiliation":[{"name":"Pediatric Hematology Oncology Azienda Ospedaliera\u2010Universitaria Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana","family":"Topini","sequence":"additional","affiliation":[{"name":"Division of Hematology and Clinical Immunology University of 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