{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:18:58Z","timestamp":1790659138607,"version":"4.1.0"},"reference-count":65,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T00:00:00Z","timestamp":1426464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Czech Ministry of Health","award":["RVO-FNOs\/2012"],"award-info":[{"award-number":["RVO-FNOs\/2012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Plasma cell leukemia (<jats:styled-content style=\"fixed-case\">PCL<\/jats:styled-content>) is a very aggressive and rare form of malignant monoclonal gammopathy characterized by the presence of plasmocytes in peripheral blood. It is classified as primary <jats:styled-content style=\"fixed-case\">PCL<\/jats:styled-content> occuring \u2018<jats:italic>de novo<\/jats:italic>\u2019, or as secondary <jats:styled-content style=\"fixed-case\">PCL<\/jats:styled-content> in patients with relapsed\/refractory multiple myeloma. Primary <jats:styled-content style=\"fixed-case\">PCL<\/jats:styled-content> is a distinct clinicopathological entity from myeloma with different cytogenetic abnormalities and molecular findings, which are usually found only in advanced multiple myeloma. The clinical course is aggressive with short remissions and reduced overall survival. The diagnostic criteria are based on the percentage (&gt;20%) and absolute number (2\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L) of plasma cells in peripheral blood. After establishing diagnosis, induction therapy should begin promptly which is aimed to rapid disease control and to minimize the risk of early death. Intensive chemotherapy regimens and bortezomib\u2010based regimens, followed by high\u2010dose therapy with autologous stem cell transplantation, are recommended. Allogeneic transplantation can be considered in younger patients. This article reviews recent knowledge of this hematological malignancy that is associated with a very poor prognosis.<\/jats:p>","DOI":"10.1111\/ejh.12533","type":"journal-article","created":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T12:41:27Z","timestamp":1426509687000},"page":"16-26","source":"Crossref","is-referenced-by-count":43,"title":["Plasma cell leukemia: from biology to treatment"],"prefix":"10.1111","volume":"95","author":[{"given":"Tomas","family":"Jelinek","sequence":"first","affiliation":[{"name":"University Hospital Ostrava Department of Haematooncology Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fedor","family":"Kryukov","sequence":"additional","affiliation":[{"name":"University of Ostrava Faculty of Medicine Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Rihova","sequence":"additional","affiliation":[{"name":"University Hospital Brno Department of Clinical Haematology Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Hajek","sequence":"additional","affiliation":[{"name":"University Hospital Ostrava Department of Haematooncology Ostrava Czech Republic"},{"name":"University of Ostrava Faculty of Medicine Ostrava Czech Republic"},{"name":"University Hospital Brno Department of Clinical Haematology Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,16]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-282632"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1994.tb05114.x"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.4"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-007-9097-2"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.336"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.133.5.813"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90942-9"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(05)70125-8"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-408682"},{"key":"e_1_2_15_11_1","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1182\/blood.V93.3.1032","article-title":"Primary plasma cell leukemia: clinical, immunophenotypic, DNA ploidy, and cytogenetic characteristics","volume":"93","author":"Garc\u00eda\u2010Sanz R","year":"1999","journal-title":"Blood"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401211"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11080"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.81603"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04260.x"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04783.x"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1309\/ELGMGX81C2UTP55R"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.5603\/FHC.2011.0024"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.3.822"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.01.007"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-08-040410"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2876"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404403"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-009910"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06750.x"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06325.x"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705131"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-038430"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.011064"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404524"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205359"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.17.5001"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2011.01.005"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq646"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.241"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-12-931"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.4137\/CGM.S16817"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.159"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-1858"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/1042819021000029713"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2011_06_554"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-235358"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-007-9011-5"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1159\/000210555"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24700"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.312"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-002-0480-5"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr480"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22700"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20272"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20793"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1586\/era.13.4"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2011.06.010"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190802290660"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21790"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2014.893304"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190601007570"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncponc1008"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21495"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2008.03.013"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2009.04.025"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.013334"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04670.x"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.3.1196.bloodjournal8731196"},{"key":"e_1_2_15_65_1","article-title":"Has allogeneic transplantation a role in the management of plasma cell leukaemia? A study on behalf of the myeloma subcomittee of the chronic leukaemia working party of the EBMT","volume":"118","author":"Morris C","year":"2011","journal-title":"Blood (ASH Annual Meeting Abstracts)"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.350"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12533","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T07:33:36Z","timestamp":1696404816000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,16]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/ejh.12533"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12533","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,16]]}}}