{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:47:56Z","timestamp":1791301676604,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,16]],"date-time":"2015-03-16T00:00:00Z","timestamp":1426464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Asan Institute for Life Sciences","award":["2011-090"],"award-info":[{"award-number":["2011-090"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Mantle cell lymphoma (<jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>) has a heterogeneous clinical course. Although most cases show a poor prognosis, a minority has an indolent course. It is difficult to identify indolent <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> cases prospectively. T\u2010cell leukemia\/lymphoma protein 1 (<jats:styled-content style=\"fixed-case\">TCL<\/jats:styled-content>1) is expressed by several B\u2010cell lymphomas, including <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>. This study examined the expression of <jats:styled-content style=\"fixed-case\">TCL<\/jats:styled-content>1 and its prognostic relevance for <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data for 162 patients with <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> were collected. Of these, 144 cases with available tissues for tissue microarray construction and immunostaining were included in the analysis. <jats:styled-content style=\"fixed-case\">TCL<\/jats:styled-content>1 staining was quantified using the Nuclear Quant application with Pannoramic<jats:sup>\u2122<\/jats:sup> Viewer v. 1.14. High <jats:styled-content style=\"fixed-case\">TCL<\/jats:styled-content>1 expression was defined as moderate to strong nuclear and\/or cytoplasmic staining in 40% or more of the cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High <jats:styled-content style=\"fixed-case\">TCL<\/jats:styled-content>1 expression was observed in 39 of 144 samples (27.1%). Patients with low <jats:styled-content style=\"fixed-case\">TCL<\/jats:styled-content>1 expression were more likely to present with blastoid\/pleomorphic morphology (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.010). Low <jats:styled-content style=\"fixed-case\">TCL<\/jats:styled-content>1 expression was associated with significantly shorter overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>,<jats:italic> P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.006). Multivariate analysis identified low <jats:styled-content style=\"fixed-case\">TCL<\/jats:styled-content>1 expression (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.003), high\u2010risk <jats:styled-content style=\"fixed-case\">MIPI<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.027), and anemia (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.018) as adverse prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study suggests that <jats:styled-content style=\"fixed-case\">TCL<\/jats:styled-content>1 expression profile may have a role in the prediction of overall outcome in patient with <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> and call for prospective studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12539","type":"journal-article","created":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T12:15:40Z","timestamp":1424175340000},"page":"583-594","source":"Crossref","is-referenced-by-count":10,"title":["<scp>TCL<\/scp>1 expression predicts overall survival in patients with mantle cell lymphoma"],"prefix":"10.1111","volume":"95","author":[{"given":"Su\u2010Jin","family":"Shin","sequence":"first","affiliation":[{"name":"Departments of Pathology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Roh","sequence":"additional","affiliation":[{"name":"Departments of Pathology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Jeong","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Pathology Ulsan University Hospital University of Ulsan College of Medicine Ulsan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo Duk","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pathology Chonnam National University Medical School Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Man","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Chungnam National University School of Medicine Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Kee","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Pathology Hallym University Sacred Heart Hospital Hallym University College of Medicine Anyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University Boramae Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae\u2010Woon","family":"Eom","sequence":"additional","affiliation":[{"name":"Departments of Pathology University of Ulsan College of Medicine Gangneung Asan Hospital Gangneung Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hojung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology Eulji Medical Center Eulji University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Sanggye Paik Hospital Inje University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dok Hyun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Departments of Oncology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheolwon","family":"Suh","sequence":"additional","affiliation":[{"name":"Departments of Oncology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jooryung","family":"Huh","sequence":"additional","affiliation":[{"name":"Departments of Pathology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23608"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.8435"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.5.1922"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.600488"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2011.03.010"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.5045\/br.2014.49.1.1"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.036277"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-3419"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-1615"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-095331"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-230250"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.4.1421"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05716.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-117010"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2011.06.001"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp495"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.5045\/br.2014.49.1.15"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-05-155507"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08228.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07329.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-12-400580"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.148"},{"key":"e_1_2_5_24_1","first-page":"2095","article-title":"Regulation of TCL1 expression in B\u2010 and T\u2010cell lymphomas and reactive lymphoid tissues","volume":"60","author":"Narducci MG","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2000.01023.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780264"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)00039-3"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.102181599"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31802e2201"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12308-009-0036-x"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.815349"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-4079"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-6-6"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-093401"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.010264"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2006.tb01808.x"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.26.12530"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2009.01369.x"},{"key":"e_1_2_5_39_1","first-page":"151","article-title":"Identification of TCL1A as an immunohistochemical marker of adverse outcome in diffuse large B\u2010cell lymphomas","volume":"26","author":"Ramuz O","year":"2005","journal-title":"Int J Oncol"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-438937"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1783-4"},{"key":"e_1_2_5_42_1","first-page":"1","article-title":"Update on the molecular pathogenesis and targeted approaches of mantle cell lymphoma: summary of the 12th annual conference of the European Mantle Cell Lymphoma Network","volume":"20","author":"Dreyling M","year":"2014","journal-title":"Leuk Lymphoma"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12539","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T19:29:06Z","timestamp":1696361346000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,16]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/ejh.12539"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12539","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,16]]}}}