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Most (90%) patients had failed previous autologous hematopoietic stem cell transplantation. The conditioning regimens were based on combinations of thiotepa, busulfan, cyclophosphamide or fludarabine, and antithymocyte globulin. The cumulative incidence (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) of myeloid engraftment was 90% [95% confidence interval (C.I.), 74\u201398%] with a median of 18\u00a0d (range, 10\u201348). <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> of acute graft\u2010versus\u2010host disease (Gv<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>) grades <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> was 30% (95% C.I., 17\u201344%), while the incidence of chronic <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> was 42% (95% C.I., 23\u201377%). The non\u2010relapse mortality (<jats:styled-content style=\"fixed-case\">NRM<\/jats:styled-content>) at 100\u00a0d and 4\u00a0yr was 30% (95% C.I., 13\u201346%) and 47% (95% C.I., 29\u201365%), respectively. <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010related post\u2010transplant lymphoproliferative disease (<jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content>) accounted for more than one\u2010third of transplant\u2010related death, with an estimate incidence of 26% (95% C.I., 9\u201344). The incidence of relapse at 4\u00a0yr was 25% (95% C.I., 9\u201342%). Four\u2010year event\u2010free survival (<jats:styled-content style=\"fixed-case\">EFS<\/jats:styled-content>) and overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) were 28% and 30%, respectively. Despite a high <jats:styled-content style=\"fixed-case\">NRM<\/jats:styled-content> and an unexpected high incidence of <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> UCBT<\/jats:styled-content> in heavily pretreated <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients is an option for patients lacking a suitable adult donor, provided the disease is not in refractory relapse.<\/jats:p>","DOI":"10.1111\/ejh.12557","type":"journal-article","created":{"date-parts":[[2015,4,3]],"date-time":"2015-04-03T10:57:58Z","timestamp":1428058678000},"page":"128-135","source":"Crossref","is-referenced-by-count":16,"title":["Umbilical cord blood transplantation in adults with advanced hodgkin's disease: high incidence of post\u2010transplant lymphoproliferative disease"],"prefix":"10.1111","volume":"96","author":[{"given":"Jos\u00e9 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