{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T15:18:53Z","timestamp":1770995933889,"version":"3.50.1"},"reference-count":68,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T00:00:00Z","timestamp":1429833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is a rich history behind the extinct entity \u2018T\u2010cell chronic lymphocytic leukemia (T\u2010<jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>)\u2019 and the now\u2010established replacement, small\u2010cell variant of T\u2010cell prolymphocytic leukemia (T\u2010<jats:styled-content style=\"fixed-case\">PLL<\/jats:styled-content>\u2010sv). Herein, we review the history of the events, observations, and discussions that led to this replacement. We also provide a systematic analysis of all previously reported cases of T\u2010<jats:styled-content style=\"fixed-case\">PLL<\/jats:styled-content>\u2010sv as well as our four new additional cases. Despite the higher frequency of a normal karyotype and perhaps an overrepresented <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>\u2212<\/jats:sup><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>\u2212<\/jats:sup> immunophenotype among these patients (compared to T\u2010<jats:styled-content style=\"fixed-case\">PLL<\/jats:styled-content> in general) as well as bland morphology (that makes them superficially appear more similar to B\u2010<jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>), we argue that the current World Health Organization (<jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content>)\u2010based classification as T\u2010<jats:styled-content style=\"fixed-case\">PLL<\/jats:styled-content>\u2010sv is adequate and should continue for the time being. Morphologically, T\u2010<jats:styled-content style=\"fixed-case\">PLL<\/jats:styled-content>\u2010sv represents approximately one\u2010fifth of all T\u2010<jats:styled-content style=\"fixed-case\">PLL<\/jats:styled-content> cases. However, morphology alone does not determine the clinical course and should not be the basis for clinical decision making and prognostication. We propose a clonal evolution model in which mature T\u2010cell leukemias classified in the past as T\u2010<jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> are perhaps T\u2010<jats:styled-content style=\"fixed-case\">PLL<\/jats:styled-content> diagnosed early in the course of the disease. Future research using next\u2010generation sequencing, comparative genomic hybridization, and molecular array studies, including serial analyses of individual cases over time, is needed to better identify this rarely diagnosed, inherently controversial form of T\u2010cell leukemia.<\/jats:p>","DOI":"10.1111\/ejh.12560","type":"journal-article","created":{"date-parts":[[2015,4,3]],"date-time":"2015-04-03T15:02:26Z","timestamp":1428073346000},"page":"199-210","source":"Crossref","is-referenced-by-count":18,"title":["T\u2010cell chronic lymphocytic leukemia or small\u2010cell variant of T\u2010cell prolymphocytic leukemia: a historical perspective and search for consensus"],"prefix":"10.1111","volume":"95","author":[{"given":"Armin","family":"Rashidi","sequence":"first","affiliation":[{"name":"Division of Oncology Washington University School of Medicine St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen I.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Pathology Sciences Medical Group\/Sentara Laboratory Services Norfolk VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)93135-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1974.tb06769.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)92127-3"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830415)51:8<1434::AID-CNCR2820510818>3.0.CO;2-4"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1986.tb07579.x"},{"key":"e_1_2_9_7_1","first-page":"867","article-title":"Is there a T\u2010cell form of chronic lymphocytic leukemia?","volume":"6","author":"Foon KA","year":"1992","journal-title":"Leukemia"},{"key":"e_1_2_9_8_1","first-page":"916","article-title":"T\u2010cell form of chronic lymphocytic leukemia","volume":"7","author":"Neame PB","year":"1993","journal-title":"Leukemia"},{"key":"e_1_2_9_9_1","first-page":"917","article-title":"Reply to Letters to the Editors","volume":"7","author":"Foon KA","year":"1993","journal-title":"Leukemia"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1182\/blood.V86.3.1163.1163","article-title":"True T\u2010cell chronic lymphocytic leukemia: a morphologic and immunophenotypic study of 25 cases","volume":"86","author":"Hoyer JD","year":"1995","journal-title":"Blood"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.12.3269.3269"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1182\/blood.V87.8.3520.bloodjournal8783520","article-title":"Similarities between T\u2010cell chronic lymphocytic leukemia and the small\u2010cell variant of T\u2010prolymphocytic leukemia","volume":"87","author":"Matutes E","year":"1996","journal-title":"Blood"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.457995.x"},{"key":"e_1_2_9_14_1","first-page":"580","article-title":"Is T\u2010cell CLL a disease entity?","volume":"94","author":"Catovsky D","year":"1996","journal-title":"Br J Haematol"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/ajcp\/87.1.55","article-title":"New aggressive variant of suppressor\/cytotoxic T\u2010CLL","volume":"87","author":"Hui PK","year":"1987","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008349422735"},{"key":"e_1_2_9_17_1","first-page":"917","article-title":"CLL should be used only for the disease with B\u2010cell phenotype","volume":"7","author":"Matutes E","year":"1993","journal-title":"Leukemia"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008278706002"},{"issue":"1","key":"e_1_2_9_20_1","first-page":"S8","article-title":"World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues. 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