{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T10:19:36Z","timestamp":1783765176957,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T00:00:00Z","timestamp":1430870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81360263"],"award-info":[{"award-number":["No. 81360263"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study assessed the value of mean reticulocyte volume (<jats:styled-content style=\"fixed-case\">MRV<\/jats:styled-content>) for differential diagnosis of hereditary spherocytosis (<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>) so as to develop conventional and new specific screen indexes. Subjects in this study were divided into three groups: 53 cases in HS group, 217 cases in hemolytic anemia control group (109 cases of thalassemia (<jats:styled-content style=\"fixed-case\">THAL<\/jats:styled-content>), 56 cases of glucose\u20106\u2010phosphate dehydrogenase G6<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> deficiency anemia, and 52 cases of autoimmune hemolytic anemia (<jats:styled-content style=\"fixed-case\">AIHA<\/jats:styled-content>)), and 100 cases in healthy control group. We analyzed erythrocyte and reticulocyte parameters including <jats:styled-content style=\"fixed-case\">MRV<\/jats:styled-content>, mean sphered corpuscular volume, mean corpuscular hemoglobin concentration, and immature reticulocyte fraction. Results demonstrated that <jats:styled-content style=\"fixed-case\">MRV<\/jats:styled-content> was significantly lower in the <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> group but significantly higher in the <jats:styled-content style=\"fixed-case\">AIHA<\/jats:styled-content> and G6<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> deficiency anemia groups than that in the healthy control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.000). <jats:styled-content style=\"fixed-case\">MRV<\/jats:styled-content> was not significantly different between the <jats:styled-content style=\"fixed-case\">AIHA<\/jats:styled-content> and G6<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> deficiency anemia groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.977) and between the healthy control and <jats:styled-content style=\"fixed-case\">THAL<\/jats:styled-content> groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.168). The area under the <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curve of <jats:styled-content style=\"fixed-case\">MRV<\/jats:styled-content> for diagnosis of <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> was 0.942, with a standard error of 0.019, 95% confidence interval of 0.905\u20130.979, and optimal critical diagnosis point of 95.77\u00a0fL. When the <jats:styled-content style=\"fixed-case\">MRV<\/jats:styled-content> was \u226495.77\u00a0fL, the sensitivity and specificity for diagnosis of <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> were 86.80% and 91.20%, respectively. Therefore, <jats:styled-content style=\"fixed-case\">MRV<\/jats:styled-content> is a general and specific new index for screening <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> and important for differential diagnosis of different types of hemolytic anemia.<\/jats:p>","DOI":"10.1111\/ejh.12563","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T15:38:38Z","timestamp":1428939518000},"page":"170-174","source":"Crossref","is-referenced-by-count":14,"title":["Mean reticulocyte volume: a specific parameter to screen for hereditary spherocytosis"],"prefix":"10.1111","volume":"96","author":[{"given":"Yuchan","family":"Xu","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Yang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Liao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengfu","family":"Deng","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Qiu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiang","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi 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