{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:45:08Z","timestamp":1791402308676,"version":"4.3.3"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T00:00:00Z","timestamp":1430870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007357","name":"Adolf H Lundin Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007357","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Posaconazole prophylaxis during induction chemotherapy for acute myeloid leukaemia (<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>) and myelodysplastic syndromes (<jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>) has been shown to significantly decrease the incidence of invasive fungal disease (<jats:styled-content style=\"fixed-case\">IFD<\/jats:styled-content>) and increase overall survival in a trial setting, but only small real\u2010life studies have been published.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort study including consecutive patients with <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content> treated with intensive induction chemotherapy; 176 patients received fluconazole prophylaxis 2008\u20132011 and 107 patients received posaconazole prophylaxis 2011\u20132013. Only proven and probable <jats:styled-content style=\"fixed-case\">IFD<\/jats:styled-content> according to the revised <jats:styled-content style=\"fixed-case\">EORTC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MSG<\/jats:styled-content> criteria were included in the analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The two cohorts were well matched without significant differences in patient characteristics. At day 100, patients receiving posaconazole had a significantly lower incidence of total <jats:styled-content style=\"fixed-case\">IFD<\/jats:styled-content> (0.9% vs. 10.8%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), invasive aspergillosis (0% vs. 5.7%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) and invasive candidiasis (0% vs. 4.0%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). There was no significant difference in overall survival, neither at day 100 (87% in the posaconazole group vs. 85% in the fluconazole group) nor at end of follow\u2010up (78% vs. 77%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Posaconazole prophylaxis decreased the incidence of <jats:styled-content style=\"fixed-case\">IFD<\/jats:styled-content> but did not improve short\u2010term overall survival. Improved treatment efficacy of manifest <jats:styled-content style=\"fixed-case\">IFD<\/jats:styled-content> is likely to explain the lack of survival benefit.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12565","type":"journal-article","created":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T06:48:56Z","timestamp":1429166936000},"page":"175-180","source":"Crossref","is-referenced-by-count":21,"title":["Decreased invasive fungal disease but no impact on overall survival by posaconazole compared to fluconazole prophylaxis: a retrospective cohort study in patients receiving induction therapy for acute myeloid leukaemia\/myelodysplastic syndromes"],"prefix":"10.1111","volume":"96","author":[{"given":"Torsten","family":"Dahl\u00e9n","sequence":"first","affiliation":[{"name":"Department of Medicine Solna Division of Hematology Karolinska Institutet Karolinska University Hospital Stockholm 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