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These discoveries have been rapidly incorporated into evolving molecular diagnostic algorithms. Whilst many of these mutations appear to have prognostic implications, establishing\n                    <jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content>\n                    diagnosis is of immediate clinical importance with selection, implementation and the continual evaluation of the appropriate laboratory methodology to achieve this diagnosis similarly vital. The advantages and limitations of these approaches in identifying and quantitating the common\n                    <jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content>\n                    \u2010associated mutations are considered herein with particular regard to their clinical utility. The evolution of molecular diagnostic applications and platforms has occurred in parallel with the discovery of\n                    <jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content>\n                    \u2010associated mutations, and it therefore appears likely that emerging technologies such as next\u2010generation sequencing and digital\n                    <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\n                    will in the future play an increasing role in the molecular diagnosis of\n                    <jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/ejh.12578","type":"journal-article","created":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T05:10:20Z","timestamp":1430975420000},"page":"270-279","source":"Crossref","is-referenced-by-count":70,"title":["Molecular diagnostics of myeloproliferative 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