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M\u00f8ller og Hustru Chastine Mc-Kinney M\u00f8llers Fond til almene Formaal","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008398","name":"Villum Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008398","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The tumour microenvironment in classical Hodgkin's lymphoma (<jats:styled-content style=\"fixed-case\">cHL<\/jats:styled-content>) is characterised by a minor population of neoplastic Hodgkin and Reed\u2013Sternberg cells within a heterogeneous background of non\u2010neoplastic bystanders cells, including mast cells. The number of infiltrating mast cells in <jats:styled-content style=\"fixed-case\">cHL<\/jats:styled-content> has been reported to correlate with poor prognosis. We used immunohistochemistry to assess the degree of tumour\u2010infiltrating mast cells in <jats:styled-content style=\"fixed-case\">cHL<\/jats:styled-content> tissue microarrays and correlated this with clinico\u2010pathological features and prognosis in a cohort of homogeneously treated patients with Hodgkin's disease. A high degree of tumour mast cells was associated with nodular sclerosis (<jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>) subtype histology (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0002). Moreover, the number of mast cells was inversely correlated with the numbers of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>68+ and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>163+ macrophages (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003, respectively) and with the number of granzyme+ cytotoxic cells (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004). The degree of mast cell infiltration was not a prognostic factor in <jats:styled-content style=\"fixed-case\">cHL<\/jats:styled-content> of nodular sclerosis subtype. In contrast, in mixed cellularity <jats:styled-content style=\"fixed-case\">cHL<\/jats:styled-content> a high number of intratumoral mast cells correlated with significantly poorer outcome both in terms of overall (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) and event\u2010free survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01). Further studies are warranted into the biological mechanisms underlying this adverse outcome and their possible therapeutic implications.<\/jats:p>","DOI":"10.1111\/ejh.12583","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T03:08:50Z","timestamp":1431400130000},"page":"252-259","source":"Crossref","is-referenced-by-count":45,"title":["Tumour\u2010associated mast cells in classical Hodgkin's lymphoma: correlation with histological subtype, other tumour\u2010infiltrating inflammatory cell subsets and outcome"],"prefix":"10.1111","volume":"96","author":[{"given":"Maja D.","family":"Andersen","sequence":"first","affiliation":[{"name":"Department of Hematology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kamper","sequence":"additional","affiliation":[{"name":"Department of Hematology Aarhus University Hospital Aarhus 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