{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:12:17Z","timestamp":1789017137169,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,6,22]],"date-time":"2015-06-22T00:00:00Z","timestamp":1434931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the prognostic power of minimal residual disease (<jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content>) monitored by polymerase chain reaction at defined time points during early treatment in adult patients with acute lymphoblastic leukemia (<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010one patients were treated according to the <jats:styled-content style=\"fixed-case\">GMALL<\/jats:styled-content> 07\/2003 protocol and evaluated for <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> in bone marrow by specific clonal rearrangements of Ig\/<jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content> in <jats:italic><jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content><\/jats:italic> negative <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> or fusion gene transcript in <jats:italic><jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content><\/jats:italic> positive <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three\u2010year overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) was 94% in patients with <jats:italic>BCR\u2010ABL<\/jats:italic> negative ALL reaching complete molecular response (<jats:styled-content style=\"fixed-case\">CMR<\/jats:styled-content>) after the first course of chemotherapy (vs. 32% if <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> &gt;10<jats:sup>\u22124<\/jats:sup>; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Patients with <jats:styled-content style=\"fixed-case\">CMR<\/jats:styled-content> prior to the start of consolidation chemotherapy at week 11 had 3\u2010yr <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> 82% (vs. 18% if <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> &gt;10<jats:sup>\u22124<\/jats:sup>; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Patients with <jats:italic><jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content><\/jats:italic> positive <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> showed slower <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> dynamics. There was a trend to better <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> in patients with \u22654 log reduction of <jats:italic><jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content><\/jats:italic> transcript prior to <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> (92% vs. 50%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.065). None of the patients with detectable <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> (both <jats:italic><jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content><\/jats:italic> positive and negative) after <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> survived 3\u00a0yr.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> kinetics is an important tool for new prognostication models with direct clinical impact irrespective of standard prognostic factors in patients with <jats:italic><jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content><\/jats:italic> negative <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12587","type":"journal-article","created":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T15:13:40Z","timestamp":1432221220000},"page":"276-284","source":"Crossref","is-referenced-by-count":24,"title":["Early MRD response as a prognostic factor in adult patients with acute lymphoblastic leukemia"],"prefix":"10.1111","volume":"96","author":[{"given":"Cyril","family":"\u0160\u00e1lek","sequence":"first","affiliation":[{"name":"Institute of Hematology and Blood Transfusion Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franti\u0161ek","family":"Folber","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hematology and Oncology University Hospital Brno Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Fro\u0148kov\u00e1","sequence":"additional","affiliation":[{"name":"Department 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