{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T04:56:55Z","timestamp":1792299415348,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,6,22]],"date-time":"2015-06-22T00:00:00Z","timestamp":1434931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immunosuppressive therapy with antithymocyte immunoglobulin (<jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content>) and cyclosporine A is the first treatment option for severe aplastic anemia (<jats:styled-content style=\"fixed-case\">SAA<\/jats:styled-content>) patients without transplantation. Horse<jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content>is not marketed in China. Because the price of porcine<jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content>(<jats:styled-content style=\"fixed-case\">pATG<\/jats:styled-content>) is only about one\u2010third of the price of rabbit<jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content>(<jats:styled-content style=\"fixed-case\">rATG<\/jats:styled-content>), long\u2010term follow\u2010up studies of<jats:styled-content style=\"fixed-case\">pATG<\/jats:styled-content>'s efficacy will help provide valuable insights into the treatment of<jats:styled-content style=\"fixed-case\">SAA<\/jats:styled-content>. Retrospective studies were performed to analyze the clinical information of 102<jats:styled-content style=\"fixed-case\">SAA<\/jats:styled-content>patients treated with<jats:styled-content style=\"fixed-case\">pATG<\/jats:styled-content>and cyclosporine A from 1999 to 2014 in Peking Union Medical College Hospital. The median age was 29\u00a0years old (range 12\u201372). Median follow\u2010up time was 59.6\u00a0months (0.2\u2013176.8). The overall response rate was 74.5% (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>42.1%,<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>32.4%). The recurrence rate was 9.9%. The mortality rate was 16.7%. The median survival time has not been reached, and the 5\u2010year survival rate was 81.8%. Other hematologic abnormalities were observed in 7.8% of patients, including symptomatic<jats:styled-content style=\"fixed-case\">PNH<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>, and<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>. Multivariate analysis revealed there was no significant effect on survival by factors such as gender, age, severity of disease, treatment time, and<jats:styled-content style=\"fixed-case\">PNH<\/jats:styled-content>clone (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). These data have indicated<jats:styled-content style=\"fixed-case\">pATG<\/jats:styled-content>therapy combined with cyclosporine A has significant long\u2010term efficacy and high overall survival in SAA.<\/jats:p>","DOI":"10.1111\/ejh.12590","type":"journal-article","created":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T15:47:13Z","timestamp":1432223233000},"page":"291-296","source":"Crossref","is-referenced-by-count":28,"title":["Long\u2010term follow\u2010up study of porcine anti\u2010human thymocyte immunoglobulin therapy combined with cyclosporine for severe aplastic anemia"],"prefix":"10.1111","volume":"96","author":[{"given":"Miao","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital Peking Union Medical College &amp; Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[{"name":"LMIB of the Ministry of Education School of Mathematics and Systems Science Beihang University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junling","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital Peking Union Medical College &amp; 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Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital Peking Union Medical College &amp; Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tienan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital Peking Union Medical College &amp; Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huacong","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital Peking Union Medical College &amp; Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital Peking Union Medical College &amp; 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