{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:54:46Z","timestamp":1789502086390,"version":"build-2803163510"},"reference-count":58,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T00:00:00Z","timestamp":1435190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitamin C, as antioxidant, increases the efficacy of deferoxamine (DFO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the effects of vitamin C as an adjuvant therapy to the three used iron chelators in moderately iron\u2010overloaded young vitamin C\u2010deficient patients with \u03b2\u2010thalassemia major (\u03b2\u2010TM) in relation to tissue iron overload.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This randomized prospective trial that included 180 \u03b2\u2010TM vitamin C\u2010deficient patients were equally divided into three groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a060) and received DFO, deferiprone (DFP), and deferasirox (DFX). Patients in each group were further randomized either to receive vitamin C supplementation (100\u00a0mg daily) or not (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a030). All patients received vitamin C (group A) or no vitamin C (group B) were followed up for 1\u00a0yr with assessment of transfusion index, hemoglobin, iron profile, liver iron concentration (LIC) and cardiac magnetic resonance imaging (MRI) T2*.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Baseline vitamin C was negatively correlated with transfusion index, serum ferritin (SF), and LIC. After vitamin C therapy, transfusion index, serum iron, SF, transferrin saturation (Tsat), and LIC were significantly decreased in group A patients, while hemoglobin and cardiac MRI T2* were elevated compared with baseline levels or those in group B without vitamin C. The same improvement was found among DFO\u2010treated patients post\u2010vitamin C compared with baseline data. DFO\u2010treated patients had the highest hemoglobin with the lowest iron, SF, and Tsat compared with DFP or DFX subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Vitamin C as an adjuvant therapy possibly potentiates the efficacy of DFO more than DFP and DFX in reducing iron burden in the moderately iron\u2010overloaded vitamin C\u2010deficient patients with \u03b2\u2010TM, with no adverse events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.12594","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T04:11:12Z","timestamp":1432786272000},"page":"318-326","source":"Crossref","is-referenced-by-count":40,"title":["Role of vitamin C as an adjuvant therapy to different iron chelators in young \u03b2\u2010thalassemia major patients: efficacy and safety in relation to tissue iron overload"],"prefix":"10.1111","volume":"96","author":[{"given":"Mohsen S.","family":"Elalfy","sequence":"first","affiliation":[{"name":"Pediatrics Department Faculty of Medicine Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha M.","family":"Saber","sequence":"additional","affiliation":[{"name":"Child Health in Complementary Medicine National Research Center Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira Abdel Moneam","family":"Adly","sequence":"additional","affiliation":[{"name":"Pediatrics Department Faculty of Medicine Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman A.","family":"Ismail","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department Faculty of Medicine Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Tarif","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department Faculty of Medicine Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Child Health in Complementary Medicine National Research Center Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar M.","family":"Elalfy","sequence":"additional","affiliation":[{"name":"Child Health in Complementary Medicine National Research Center Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.5581\/1516-8484.20130106"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12413"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/435683"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1345.015"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040620712450252"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.9.13.2391"},{"key":"e_1_2_6_8_1","first-page":"CD007476","article-title":"Deferasirox for managing iron overload in people with thalassaemia","volume":"2","author":"Meerpohl JJ","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13309-0"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2007.04.001"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2006.05.005"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6603(08)60843-0"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00031.2007"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1191\/0960327106ht637oa"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2006.219"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715769900300491"},{"key":"e_1_2_6_17_1","first-page":"1858","article-title":"Vitamin C deficiency in patients on long\u2010term deferasirox without supplementation","volume":"112","author":"Sarantos K","year":"2008","journal-title":"ASH Annual Meeting Abstracts"},{"key":"e_1_2_6_18_1","first-page":"163","article-title":"Idiopathic and bantu hemochromatosis. 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