{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:15:22Z","timestamp":1789964122921,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T00:00:00Z","timestamp":1435881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Achieving a major molecular response (<jats:styled-content style=\"fixed-case\">MMR<\/jats:styled-content>) is the goal of imatinib therapy for chronic myeloid leukemia. However, the association between gender, <jats:italic><jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content><\/jats:italic> transcript type, and age with <jats:styled-content style=\"fixed-case\">MMR<\/jats:styled-content> is not well understood and often controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed 166 patients who have been treated with imatinib for up to 10\u00a0yr.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Men had a lower <jats:styled-content style=\"fixed-case\">MMR<\/jats:styled-content> rate than women (63.3% vs. 81.6%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006) and a shorter time to relapse (median 354 vs. 675\u00a0d, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.049), while patients with b3a2 or with both b3a2 and b2a2 break point transcripts had higher <jats:styled-content style=\"fixed-case\">MMR<\/jats:styled-content> rate than those with b2a2 (81.8%, 77.1% vs. 60.7%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.023 for b3a2 vs. b2a2, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.043 for both vs. b2a2). A striking difference was found between men with b2a2 and women with both b2a2 and b3a2 in terms of <jats:styled-content style=\"fixed-case\">MMR<\/jats:styled-content> rate (43.8% vs. 88.9%), <jats:styled-content style=\"fixed-case\">MMR<\/jats:styled-content> rate within 6\u00a0months (7.1% vs. 62.5%) and the time to <jats:styled-content style=\"fixed-case\">MMR<\/jats:styled-content> (median d 493 vs. 159, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.036).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both gender and <jats:italic><jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content><\/jats:italic> transcript, but not age, were significantly associated with the molecular response. Men with b2a2 represent a less favorable group in their response to imatinib treatment and may need alternative therapy regimen and closer monitoring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12597","type":"journal-article","created":{"date-parts":[[2015,6,9]],"date-time":"2015-06-09T16:40:02Z","timestamp":1433868002000},"page":"360-366","source":"Crossref","is-referenced-by-count":35,"title":["Gender and <i><scp>BCR<\/scp>\u2010<scp>ABL<\/scp><\/i> transcript type are correlated with molecular response to imatinib treatment in patients with chronic myeloid leukemia"],"prefix":"10.1111","volume":"96","author":[{"given":"Han\u2010Xin","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Pathology and Molecular Medicine McMaster University Hamilton ON Canada"},{"name":"Hamilton Regional Laboratory Medicine Program Hamilton Health Science Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Sjaarda","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine McMaster University Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocob","family":"Dyck","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine McMaster University Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randa","family":"Stringer","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine McMaster University Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Hillis","sequence":"additional","affiliation":[{"name":"Department of Oncology McMaster University Juravinski Hospital Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Harvey","sequence":"additional","affiliation":[{"name":"Hamilton Regional Laboratory Medicine Program Hamilton Health Science Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine McMaster University Hamilton ON Canada"},{"name":"Hamilton Regional Laboratory Medicine Program Hamilton Health Science Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Ainsworth","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Western University London ON Canada"},{"name":"Molecular Genetics Laboratory London Health Sciences Centre London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Leber","sequence":"additional","affiliation":[{"name":"Department of Oncology McMaster University Juravinski Hospital Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Pare","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine McMaster University Hamilton ON Canada"},{"name":"Hamilton Regional Laboratory Medicine Program Hamilton Health Science Hamilton ON Canada"},{"name":"Population Health Research Institute Hamilton Health Sciences McMaster University; McMaster University Hamilton ON Canada"},{"name":"Population Genomics Program Chanchlani Research Centre McMaster University; McMaster University Hamilton ON Canada"},{"name":"Department of Clinical Epidemiology and Biostatistics McMaster University; McMaster University Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bekim","family":"Sadikovic","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine McMaster University Hamilton ON Canada"},{"name":"Department of Pathology and Laboratory Medicine Western University London ON Canada"},{"name":"Molecular Genetics Laboratory London Health Sciences Centre London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-144790"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/315550a0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062867"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.38"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-01-0092"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.096537"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-2139"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-06-161737"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-036012"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-373902"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1103"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.9499"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402680"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04200.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-578567"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-10-462291"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403756"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2012.3972"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904293401706"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00411-013-0507-4"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197808)42:2<669::AID-CNCR2820420238>3.0.CO;2-L"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(83)90004-7"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.11.011"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804895105"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.009134"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.6026\/97320630010108"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.4238\/vol7-4gmr485"},{"key":"e_1_2_7_29_1","first-page":"803","article-title":"Differential molecular response of the transcripts B2A2 and B3A2 to imatinib mesylate in chronic myeloid leukemia","volume":"4","author":"Lemos JA","year":"2005","journal-title":"Genet Mol Res"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-013-0508-9"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2008.01170.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-012-0348-z"},{"key":"e_1_2_7_33_1","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1182\/blood.V78.12.3125.3125","article-title":"A possible correlation between the type of bcr\u2010abl hybrid messenger RNA and platelet count in Philadelphia\u2010positive chronic myelogenous leukemia","volume":"78","author":"Inokuchi K","year":"1991","journal-title":"Blood"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb08362.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(92)90039-A"},{"key":"e_1_2_7_36_1","first-page":"1104","article-title":"Analysis of the clinical relevance of the breakpoint location within M\u2010BCR and the type of chimeric mRNA in chronic myelogenous leukemia","volume":"9","author":"Rozman C","year":"1995","journal-title":"Leukemia"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12597","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12597","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T23:46:22Z","timestamp":1696290382000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,3]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1111\/ejh.12597"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12597","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,3]]}}}