{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:10:08Z","timestamp":1762506608039},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,8,20]],"date-time":"2015-08-20T00:00:00Z","timestamp":1440028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"Abstract<\/jats:title>Patients with essential thrombocythemia (ET<\/jats:styled-content>) often suffer from neurological symptoms (NS<\/jats:styled-content>) not ever resulting from previous thrombotic cerebral events (TCE<\/jats:styled-content>). We reported NS<\/jats:styled-content> occurred in 282 patients, in order to identify the factors influencing ET<\/jats:styled-content>\u2010related NS<\/jats:styled-content> in the absence of TCE<\/jats:styled-content>, and the response to therapy. Overall, 116 of 282 patients (41%) presented NS<\/jats:styled-content>; 101 of them (87%) reported subjective transient and fluctuating NS<\/jats:styled-content>, without concurrent TCE<\/jats:styled-content>, which we defined as ET<\/jats:styled-content>\u2010related NS<\/jats:styled-content>, by frequency: cephalalgia, chronic paresthesias, dizziness or hypotension, visual disturbances, and tinnitus. In univariate analysis, ET<\/jats:styled-content>\u2010related NS<\/jats:styled-content> resulted more frequently in young people (P<\/jats:italic>\u00a0=\u00a00.017) and in females (P<\/jats:italic>\u00a0=\u00a00.025). We found a higher prevalence of JAK<\/jats:styled-content>2V617F mutation in ET<\/jats:styled-content>\u2010related NS<\/jats:styled-content> patients (P<\/jats:italic>\u00a0=\u00a00.021). In multivariate analysis, gender (P<\/jats:italic>\u00a0=\u00a00.024) and JAK<\/jats:styled-content>2V<\/jats:styled-content>617F<\/jats:styled-content> mutation (P<\/jats:italic>\u00a0=\u00a00.041) remained significantly associated with the development of ET<\/jats:styled-content>\u2010related NS<\/jats:styled-content>, with a risk of about four times higher for JAK<\/jats:styled-content>2V<\/jats:styled-content>617F<\/jats:styled-content>\u2010mutated patients (OR<\/jats:styled-content>\u00a0=\u00a03.75). Ninety\u2010seven of 101 patients with ET<\/jats:styled-content>\u2010related NS<\/jats:styled-content> received an antiplatelet (AP<\/jats:styled-content>) agent at the time of NS<\/jats:styled-content>, whereas only selected high\u2010risk ET<\/jats:styled-content>\u2010related NS<\/jats:styled-content> patients were treated with a cytoreductive drug, according to the published guidelines and similarly to patients without NS<\/jats:styled-content>. We observed that only 32 of 97 (33%) patients with ET<\/jats:styled-content>\u2010related NS<\/jats:styled-content> achieved a complete response after AP<\/jats:styled-content> treatment. Among the 65 non\u2010responder patients, 36 (55.4%) improved NS<\/jats:styled-content> after the introduction of cytoreductive therapy; therefore, the addition of cytoreductive treatment should be considered in this setting.<\/jats:p>","DOI":"10.1111\/ejh.12638","type":"journal-article","created":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T16:08:52Z","timestamp":1437667732000},"page":"593-601","source":"Crossref","is-referenced-by-count":8,"title":["Neurological symptoms in essential thrombocythemia: impact of JAK<\/scp>2V<\/scp>617F<\/scp> mutation and response to therapy"],"prefix":"10.1111","volume":"96","author":[{"given":"Andrea","family":"Aroldi","sequence":"first","affiliation":[{"name":"Hematology Division San Gerardo Hospital University of Milano\u2010Bicocca Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Cecchetti","sequence":"additional","affiliation":[{"name":"Hematology Division San Gerardo Hospital University of 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Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena Maria","family":"Elli","sequence":"additional","affiliation":[{"name":"Hematology Division San Gerardo Hospital University of Milano\u2010Bicocca Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-270033"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.8436"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.13346"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra063728"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1182\/asheducation.V2012.1.561.3807838","article-title":"The spectrum of JAK2\u2010positive myeloproliferative neoplasms","volume":"2012","author":"Kiladjian JJ","year":"2012","journal-title":"Hematology Am Soc 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