{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:21:24Z","timestamp":1789676484885,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T00:00:00Z","timestamp":1442361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to report the long\u2010term outcomes in patients with multiple myeloma (<jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>) who receive dialysis treatment for acute kidney injury (<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>) due to myeloma cast nephropathy and subsequently recover renal function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients presenting with dialysis\u2010dependent <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> secondary to myeloma cast nephropathy and subsequently recovering independent renal function between January 2005 and December 2012 were included in this study. Both renal and haematological parameters were collected at multiple time points as part of routine clinic practice. Factors associated with renal function and overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four patients fulfilled the criteria for inclusion. Mean age was 62.1\u00a0years; 75% were male and 75% were of White ethnicity. The median <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> was 64.1\u00a0months (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 34.8\u201393.3). Twenty\u2010three (95.8%) patients remained dialysis\u2010independent until death or end of follow\u2010up; one patient required further haemodialysis treatment during the follow\u2010up period. The independent determinant of worse <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> was a known history of chronic kidney disease (<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>) at presentation. Shorter length of time on haemodialysis and higher percentage reduction in clonal serum <jats:styled-content style=\"fixed-case\">FLC<\/jats:styled-content> at day 21 from baseline predicted better excretory renal function (estimated glomerular filtration rate) at 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this series, the large majority of patients with <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> and dialysis\u2010dependent <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> secondary to myeloma cast nephropathy who recovered independent renal function had no requirement for further dialysis. Survival following recovery of renal function is good, and early variables are independently associated with survival and future renal function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12644","type":"journal-article","created":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T17:24:53Z","timestamp":1438881893000},"page":"610-617","source":"Crossref","is-referenced-by-count":25,"title":["Patients with multiple myeloma have excellent long\u2010term outcomes after recovery from dialysis\u2010dependent acute kidney injury"],"prefix":"10.1111","volume":"96","author":[{"given":"Punit","family":"Yadav","sequence":"first","affiliation":[{"name":"Department of Renal Medicine University Hospitals Birmingham NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin A.","family":"Hutchison","sequence":"additional","affiliation":[{"name":"Department of Medicine Hawke's Bay District Health Board Hastings New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kolitha","family":"Basnayake","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine Brighton and Sussex University Hospitals NHS Trust Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Stringer","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine University Hospitals Birmingham NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Jesky","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine University Hospitals Birmingham NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"Fifer","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine University Hospitals Birmingham NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kym","family":"Snell","sequence":"additional","affiliation":[{"name":"Department of Health and Population Sciences University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Pinney","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine University Hospitals Birmingham NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark T.","family":"Drayson","sequence":"additional","affiliation":[{"name":"Division of Immunity and Infection University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Haematology University Hospitals Birmingham NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Cockwell","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine University Hospitals Birmingham NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2000.90221.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.131"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb05400.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp488"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp679"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.313"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt483"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2015.20"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101819"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04590908"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70442-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404284"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24035"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr773"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.115204"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11463"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190801930506"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/08860229809045152"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.17.1889"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.333"},{"key":"e_1_2_6_22_1","first-page":"1","article-title":"Utility of the immunoglobulin free light chain assay for plasma cell disorders","volume":"2015","author":"Gertz MA","year":"2015","journal-title":"Leuk Lymphoma"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010080857"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.1060"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07303.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11534"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-300863"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12644","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12644","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:55:38Z","timestamp":1695570938000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,16]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/ejh.12644"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12644","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,16]]}}}