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Most of the parameters of MBD signalling correlated with traditional markers of bone turnover.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>All the signalling pathways were activated in MM with more pronounced osteoclastogenesis in comparison with bone formation but not in MGUS regardless of its risk category, suggesting that MBD is not activated in MGUS until the process of transformation into MM. The parameters of MBD signalling might precede the increase of conventional parameters of bone turnover suggesting their possible role in early indication of anti\u2010resorption therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12708","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T14:24:39Z","timestamp":1448634279000},"page":"201-207","source":"Crossref","is-referenced-by-count":5,"title":["Prospective study of signalling pathways in myeloma bone disease with regard to activity of the disease, extent of skeletal involvement and correlation to bone turnover markers"],"prefix":"10.1111","volume":"97","author":[{"given":"Jiri","family":"Minarik","sequence":"first","affiliation":[{"name":"Department of Hemato\u2010Oncology Faculty of Medicine and Dentistry Palacky University Olomouc and University Hospital Olomouc Olomouc Czech 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