{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:02:41Z","timestamp":1778889761749,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T00:00:00Z","timestamp":1453161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Plasmablastic lymphoma (<jats:styled-content style=\"fixed-case\">PBL<\/jats:styled-content>) is a rare subtype of non\u2010Hodgkin lymphomas (<jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>) strongly associated with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection, even if cases in other immunosuppressed patients such as solid organ transplant recipients and in immunocompetent individuals have been increasingly reported. Current treatment strategy for <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010negative patients is similar to <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> as first\u2010line treatment, but durable remissions are seldom observed. Anthracycline\u2010containing regimens could be too toxic for elderly patients and\/or with cardiac failure, because a non\u2010pegylated liposomal doxorubicin (<jats:styled-content style=\"fixed-case\">NLD<\/jats:styled-content>) could be used in this field. Bortezomib, a proteasome inhibitor currently approved for patients with multiple myeloma and relapsed mantle\u2010cell lymphoma, has recently showed clinical activity in <jats:styled-content style=\"fixed-case\">PBL<\/jats:styled-content> patients. Herein, we report a rapid and long\u2010term remission of a <jats:styled-content style=\"fixed-case\">PBL<\/jats:styled-content> patient with cardiac failure and that had previously received a double kidney transplant, treated front\u2010line with <jats:styled-content style=\"fixed-case\">COMP<\/jats:styled-content> (with a <jats:styled-content style=\"fixed-case\">NLD<\/jats:styled-content> substituted for doxorubicin) followed by subcutaneous bortezomib consolidation. We suggest first\u2010line treatment outcome is determinant for <jats:styled-content style=\"fixed-case\">PBL<\/jats:styled-content> patients. Bortezomib has a promising role and should be incorporated in future clinical trials and <jats:styled-content style=\"fixed-case\">NLD<\/jats:styled-content> could represent a suitable option for patients with cardiac failure or high cardiovascular risk.<\/jats:p>","DOI":"10.1111\/ejh.12732","type":"journal-article","created":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T11:54:39Z","timestamp":1451476479000},"page":"650-654","source":"Crossref","is-referenced-by-count":16,"title":["Long\u2010term remission in a case of plasmablastic lymphoma treated with <scp>COMP<\/scp> (cyclophosphamide, liposomal doxorubicin, vincristine, prednisone) and bortezomib"],"prefix":"10.1111","volume":"96","author":[{"given":"Emanuele","family":"Cencini","sequence":"first","affiliation":[{"name":"Unit of Hematology Azienda Ospedaliera Universitaria Senese, University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Fabbri","sequence":"additional","affiliation":[{"name":"Unit of Hematology Azienda Ospedaliera Universitaria Senese, University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna","family":"Guerrini","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Neuro Sciences Diagnostic Imaging, Azienda Ospedaliera Universitaria Senese, University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Antonietta","family":"Mazzei","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Neuro Sciences Diagnostic Imaging, Azienda Ospedaliera Universitaria Senese, University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vania","family":"Rossi","sequence":"additional","affiliation":[{"name":"Unit of Nuclear Medicine Ospedale S. Donato Arezzo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Bocchia","sequence":"additional","affiliation":[{"name":"Unit of Hematology Azienda Ospedaliera Universitaria Senese, University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,19]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"WHO Classification of Tumors of Haematopoietic and Lymphoid Tissues","author":"Swerdlow S","year":"2008"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000234"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-10-567479"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.9401"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2014.894187"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3816\/CLML.2010.n.074"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2024"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000350325"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2014.03.002"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.2403"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2010.516040"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn656"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.30.0038"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2009.01235.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13300"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-015-0053-0"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12732","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12732","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:56:15Z","timestamp":1695570975000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,19]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/ejh.12732"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12732","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,19]]}}}