{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:08:56Z","timestamp":1790244536447,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T00:00:00Z","timestamp":1456444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Emil Andersson Research Fund"},{"name":"Nordic CML Study Group"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The clinical outcome for patients with chronic myeloid leukemia (<jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>) has improved dramatically following the introduction of tyrosine kinase inhibitors. An improved survival, combined with a constant incidence, is expected to increase the prevalence of <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>. However, data on the prevalence of <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> remain scarce. We examined the overall and relative (age and gender matched) survival and assessed the past, present, and projected future prevalence of <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> in Sweden. Data on all patients diagnosed with <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> between 1970 and 2012 were retrieved from the Swedish Cancer Register and the Swedish Cause of Death Register. The 5\u2010year overall survival increased from 0.18 to 0.82, during the observed time period. Between 2006 and 2012, the 5\u2010year relative survival was close to normal for 40\u2010year\u2010old, but considerably lower for 80\u2010year\u2010old <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> patients. The observed prevalence tripled from 1985 to 2012, from 3.9 to 11.9 per 100 000 inhabitants. Assuming no further improvements in relative survival, the prevalence is projected to further increase by 2060 to 22.0 per 100 000 inhabitants (2587 persons in Sweden). The projected dramatic increase in <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> prevalence has major medical and health economic implications and needs to be considered in planning how to organize future care of <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> patients.<\/jats:p>","DOI":"10.1111\/ejh.12743","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T08:47:16Z","timestamp":1454402836000},"page":"387-392","source":"Crossref","is-referenced-by-count":40,"title":["Population\u2010based assessment of chronic myeloid leukemia in Sweden: striking increase in survival and prevalence"],"prefix":"10.1111","volume":"97","author":[{"given":"Niklas","family":"Gunnarsson","sequence":"first","affiliation":[{"name":"Department of Public Health and Clinical Medicine Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Sandin","sequence":"additional","affiliation":[{"name":"Regional Cancer Centre Uppsala\u2010\u00d6rebro Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"H\u00f6glund","sequence":"additional","affiliation":[{"name":"Department of Medical Science and Division of Hematology University Hospital Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif","family":"Stenke","sequence":"additional","affiliation":[{"name":"Department of Hematology Karolinska University Hospital and Department of Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Bj\u00f6rkholm","sequence":"additional","affiliation":[{"name":"Department of Hematology Karolinska University Hospital and Department of Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Lambe","sequence":"additional","affiliation":[{"name":"Regional Cancer Centre Uppsala\u2010\u00d6rebro Uppsala Sweden"},{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla","family":"Olsson\u2010Str\u00f6mberg","sequence":"additional","affiliation":[{"name":"Department of Medical Science and Division of Hematology University Hospital Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Richter","sequence":"additional","affiliation":[{"name":"Department of Hematology and Vascular Disorders Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Sj\u00e4lander","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-358135"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11316"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-330332"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.34.7146"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-004266"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-015-2314-2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","unstructured":"CormS MicolJ LeroyerA et al.Kinetic of chronic myeloid leukaemia (CML) prevalence in Northern France since the introduction of imatinib. 2008.","DOI":"10.1200\/jco.2008.26.15_suppl.7088"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.05.024"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26679"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2014.953141"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860802247664"},{"key":"e_1_2_8_13_1","unstructured":"Statistics Sweden.http:\/\/www.scb.se."},{"key":"e_1_2_8_14_1","unstructured":"The Swedish National Board of Health and Welfare.http:\/\/www.socialstyrelsen.se."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19961101)78:9<2004::AID-CNCR23>3.0.CO;2-#"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X0900900206"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.5581\/1516-8484.20140014"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.745525"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-04-495598"},{"key":"e_1_2_8_20_1","unstructured":"Register reports by the Swedish Society of Hematology.http:\/\/www.sfhem.se\/rapporter-blodcancerregistret."},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70233-3"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.62.4718"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13346"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841868409136026"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fejh.12743","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.12743","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:02:28Z","timestamp":1695556948000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.12743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,26]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/ejh.12743"],"URL":"https:\/\/doi.org\/10.1111\/ejh.12743","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,26]]}}}