{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T23:58:07Z","timestamp":1774396687884,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T00:00:00Z","timestamp":1458691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006313","name":"Barncancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To study Hodgkin lymphoma (<jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content>) microenvironment in a Swedish paediatric population and its relation to clinical parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Tumour tissue from classical <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">cHL<\/jats:styled-content>) (<jats:italic>n<\/jats:italic> = 87) and nodular lymphocyte predominant <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">NLPHL<\/jats:styled-content>) (<jats:italic>n<\/jats:italic> = 11) was investigated for Epstein\u2010Barr Virus (<jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>) and analysed for eosinophils, mast cells and macrophages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In <jats:styled-content style=\"fixed-case\">cHL<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EBV<\/jats:styled-content> positivity was more common in low age (<jats:italic>P<\/jats:italic> &lt; 0.001) and in mixed cellularity (<jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>) (<jats:italic>P<\/jats:italic> &lt; 0.001). Higher mast cell infiltration was seen in stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> (<jats:italic>P<\/jats:italic> &lt; 0.001), and with presence of B\u2010symptoms (<jats:italic>P<\/jats:italic> = 0.01). Cases with high mast cell counts displayed higher erythrocyte sedimentation rate (<jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content>), lower haemoglobin and albumin levels. Higher macrophage infiltration was seen in stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0.02) and there was elevated <jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content> and neutrophil count. All <jats:styled-content style=\"fixed-case\">NLPHL<\/jats:styled-content> cases were <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> negative, had lower rates of inflammatory cells and lower degree of inflammatory reaction in laboratory parameters. There was no difference in survival estimates with regard to infiltration of inflammatory cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Higher levels of mast cells and macrophages in <jats:styled-content style=\"fixed-case\">cHL<\/jats:styled-content> tumours reflected the clinical presentation in laboratory parameters, B\u2010symptoms and more advanced stages. <jats:styled-content style=\"fixed-case\">NLPHL<\/jats:styled-content> differs from <jats:styled-content style=\"fixed-case\">cHL<\/jats:styled-content> in numbers of inflammatory cells in the tumour, and in laboratory parameters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.12747","type":"journal-article","created":{"date-parts":[[2016,2,13]],"date-time":"2016-02-13T15:30:30Z","timestamp":1455377430000},"page":"430-438","source":"Crossref","is-referenced-by-count":28,"title":["The role of tumour\u2010infiltrating eosinophils, mast cells and macrophages in Classical and Nodular Lymphocyte 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