{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:14:52Z","timestamp":1789132492970,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T00:00:00Z","timestamp":1459296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001219","name":"Lymphoma Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The purpose of this study was to describe the clinical characteristics and outcomes in cardiac non\u2010Hodgkin's lymphoma (\n                      <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective analysis of 94 cases of\n                      <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>\n                      with biopsy\u2010proven cardiac involvement in PubMed between 1990 and 2015.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among cases with cardiac involvement, diffuse large B\u2010cell lymphoma was the most common histologic subtype (58%), followed by T\u2010cell lymphoma (16%), Burkitt's lymphoma (9%), and small lymphocytic lymphoma (6%). Symptomatic heart failure was the most common clinical presentation (34%), and 20% of patients had no cardiac symptoms. Median survival was 3 months (range, 0\u201372) among all patients. Patients who presented with heart failure had inferior outcomes. Patients with primary, vs. secondary, cardiac involvement had a trend toward superior outcomes. Importantly, chemotherapy treatment was associated with a prolongation in median survival (18 vs. 1 month,\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      0.16, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      , 0.47\u20130.54,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0003), and patients diagnosed in the chemo\u2010immunotherapy era demonstrated a trend toward better outcomes. Median survival was not reached among patients with B\u2010cell malignancies who were alive for 1 month after the diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Pathologic lymphomatous involvement of cardiac tissue should be considered in the evaluation of patients with\n                      <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>\n                      . Durable remissions can be achieved in B\u2010cell\n                      <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>\n                      with cardiac involvement, and thus, therapy should be considered in such cases.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.12751","type":"journal-article","created":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T03:16:19Z","timestamp":1456974979000},"page":"445-452","source":"Crossref","is-referenced-by-count":76,"title":["Cardiac non\u2010Hodgkin's lymphoma: clinical characteristics and trends in survival"],"prefix":"10.1111","volume":"97","author":[{"given":"Max J.","family":"Gordon","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Oregon Health &amp; Sciences University Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Danilova","sequence":"additional","affiliation":[{"name":"Pathology &amp; Lab Medicine 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